Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The incidence of diabetes and its complications are on a rise the risk of lower extremity amputations is 15 fold higher in diabetics as compared to non‐diabetics. Apart from conventional methods to facilitate wound healing various new methods are emerging such as cellular therapies which include platelet‐rich plasma (PRP), collagen based wound dressing. Present study was aimed to study therapeutic role of platelet rich plasma in healing of diabetic foot ulcers. Present study was single‐center, prospective, comparative study, conducted patients with 40‐65 years age, both sexes presenting with diabetic ulcer foot, type 1 or type 2 diabetes mellitus. Fifty patients were randomly assigned to two groups as study group (freshly prepared platelet rich plasma dressing) and control group (normal saline dressing). Mean age, gender, ulcer onset, site of ulcer and anti‐diabetic drugs were comparable in both groups & difference was not significant statistically (p>0.05). Among majority of cases had 15‐25% of wound contraction (76%), while controls had 5‐15% of wound contraction (96%) and difference was statistically significant (p<0.001). Mean% of area reduction was higher in study Group (33.746±3.968) compared to control group (12.822±1.916) and difference was statistically significant (p<0.001). Among cases mean duration of wound contraction was 4.488±0.409 weeks, which was lesser than controls (6.188±0.391 weeks) and difference was statistically significant (p<0.001). Platelet Rich Plasma showed faster and better healing rates among the study group. Ulcer area reduction and percentage reduction of ulcer size was better in Platelet Rich Plasma group.
How to cite this article:
K.A. Malar Vannan and A. Sivapriya. Clinical Study of Therapeutic Role of Platelet Rich Plasma in Healing of Diabetic Foot Ulcers.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.83.87
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.83.87