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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Re‐Visiting the Last Resort: A Study of Colistin Susceptibility in Carbapenem Resistant Gram Negative Bacilli

Madhumanti Mandal, Malabika Biswas, Abhishek Sengupta, Banya Chakraborty and Anindita Rakshit
Page: 69-74 | Received 22 Nov 2023, Published online: 17 Dec 2023

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https://doi.org/10.36478/10.59218/makrjms.2024.2.69.74

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Abstract

Increasing antibiotic resistance in multidrug resistant (MDR) gram negative bacteria contributes to increased morbidity and mortality. Colistin, a repurposed drug, has appeared as a last resort of treatment in the mid‐1990s against MDR gram negative bacteria but unfortunately, rapid global resistance towards colistin has come out following its re‐emergence. So it is very important to detect the colistin susceptibility in carbapenem resistant gram negative bacteria. An observational, crosssectional study was conducted in the Bacteriology Unit, Department Of Microbiology at the Calcutta School of Tropical Medicine. Clinical samples were collected from the indoor patients for a period of 2.5 months. Isolation of carbapenem resistant gram negative bacteria along with antimicrobial susceptibility testing was performed using conventional laboratory methods as well as by automated Vitek 2 compact system. Subsequently broth microdilution was done for detection of colistin susceptibility. Results were tabulated and analyzed using WHONET software. During the study period, 461 samples showed growth in culture, of which 182(39.4%) were gram negative bacilli.73 isolates (40%) showed carbapenem resistance. Four isolates were found to be resistant to colistin by automated methods (Vitek 2). However by colistin broth micro dilution method, all isolates exhibited 100% susceptibility to colistin. The high incidence (40%) of carbapenem resistance in this study is ominous. Both false susceptible as well as false colistin resistant reports should be viewed equally gravely. Further studies are required to establish an agreeable method for detection of colistin susceptibility.

How to cite this article:

Madhumanti Mandal, Malabika Biswas, Abhishek Sengupta, Banya Chakraborty and Anindita Rakshit. Re‐Visiting the Last Resort: A Study of Colistin Susceptibility in Carbapenem Resistant Gram Negative Bacilli.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.69.74
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.69.74