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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Study of CK‐MB Levels in Asphyxiated Neonates Admitted in Neonatal Intensive Care Unit (NICU) at Tertiary Care Hospital

Sarfaraz Ahmed Manzoor Ahmed, Nagesh Lonikar, Sudhakar Bantewad, Aakif Basma and Saba
Page: 63-68 | Received 20 Nov 2023, Published online: 17 Dec 2023

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https://doi.org/10.36478/10.59218/makrjms.2024.2.63.68

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Abstract

Perinatal asphyxia is a lack of blood flow or gas exchange to or from the foetus in the period immediately before, during, or after the birth process. Perinatal asphyxia is an important cause of admission to neonatal intensive care units (NICU) with multi organ dysfunction. CK‐ MB is one of the three isoenzymes of creatine Kinase and is expressed in myocardial muscle and in very small amounts in skeletal muscle. There is evidence that CK‐MB levels are significantly elevated in asphyxiated infants compared with controls. CK‐MB may be helpful in identifying infants with neonatal hypoxic ischemia who have cardiovascular compromise but may be more useful as part of a predictive model for poor outcome following neonatal hypoxic ischemia. The study was conducted in Neonatal Intensive care unit of a tertiary care centre from February 2021 to August 2022. 203 Neonates who have been clinically diagnosed as perinatal asphyxia admitted to NICU over a period of one and half years were included in the study. Detailed demographic data with respect to maternal history birth events, Apgar score, sex of the baby and weight of the baby was recorded on the Pre‐coded proforma. Data was entered from case record form in excel sheet. Care was taken to enter data accurately. Majority of neonates post‐delivery, needed bag and mask resuscitation (80.30%), did not cry (81.7%), few had delayed cry (18.3%) with 60.1% in normal cry tone and 39.9% had poor cry tone activity. Majority of neonates needed oxygen supply (80.30%), anticonvulsants (47.4%), inotropes (40.4%) and few needed ventilatory support (19.70%). CK‐MB can be very useful to differentiate HIE newborns which will help in appropriate management and better outcome of these new‐borns. Evaluation of CK‐ MB levels as a marker of severity of perinatal asphyxia shows promising results.

How to cite this article:

Sarfaraz Ahmed Manzoor Ahmed, Nagesh Lonikar, Sudhakar Bantewad, Aakif Basma and Saba . Study of CK‐MB Levels in Asphyxiated Neonates Admitted in Neonatal Intensive Care Unit (NICU) at Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.63.68
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.63.68