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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Quantitative Analysis in Terms of Counts of Activated Platelet by Flow Cytometry at Tertiary Health Care Centre of Central India

Gourav Silawat, Ashutosh Singh, Sachin Sharma, Sanjay Silawat and Aman Shakya
Page: 36-40 | Received 22 Oct 2023, Published online: 01 Nov 2023

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https://doi.org/10.36478/10.59218/makrjms.2024.2.36.40

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Abstract

Platelet transfusions are the primary therapy for thrombocytopenia due to various causes. Since traditional function evaluations have limitations, research into platelet function has drawn interest beyond mere counting. This study aims to conduct quantitative analysis in terms of counts of activated platelet by flow cytometry. The current study, which had a cross‐sectional design, was carried out at the MGM Medical College and M.Y. Hospital in Indore’s transfusion medicine department. A total of 105 study participants were enrolled in this investigation. Activated platelet counts were quantitatively analyzed by flow cytometry in various platelet products. Platelet counts in the platelet concentrate category ranged from 1177.704±132.40 103 mL‐1 on day 1 to 1173.224±131.79 103 mL‐1 on day 4. Day 1 platelet count in the platelet rich plasma category was 496.3198± 18.96 103/ml, whereas day 4 platelet count was 492.12±18.87 103 mL-1. Researchers discovered that platelet counts were highest on days 1 and 4 when they came from a single donor. The difference observed in mean platelet counts in SDP (Single donor platelet) was 6.09×103 μL‐1 whereas this difference in mean platelet counts in PC was 4.48×103 μL‐1. The difference noted was 4.19×103 μL-1 for mean platelet counts in Platelet rich plasma. Conclusion: According to this research, platelet activity declines from day 1 to day 4, yet they are still well conserved at the conclusion of that period. Based on our findings, SDP is preferable to both PC and PRP in terms of platelet count. Activated platelets in various platelet products may be analyzed qualitatively with the use of flow cytometry.

How to cite this article:

Gourav Silawat, Ashutosh Singh, Sachin Sharma, Sanjay Silawat and Aman Shakya. Quantitative Analysis in Terms of Counts of Activated Platelet by Flow Cytometry at Tertiary Health Care Centre of Central India.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.36.40
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.36.40