Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Osteomyelitis is defined as an inflammation of the bone caused by an infecting organism. Osteomyelitis can be classified as acute, subacute, or chronic, depending on the duration of symptoms. The mechanism of infection can be exogenous or hematogenous. Exogenous osteomyelitis is caused by open fractures, surgery (iatrogenic), or contiguous spread from infected local tissue. To isolate and identify the bacteria causing osteomyelitis in patients attending orthopaedic outpatient department in Calcutta National Medical College, a tertiary care hospital. To study the antibiogram sensitivity and resistance pattern of the bacteria isolated. The present study was a Prospective, Descriptive study. This Study was conducted from 12 months at Department of Orthopaedics, Calcutta National Medical College. In our study, 4 (8.0%) patients had osteomyelitis in Distal tibia, 4 (8.0%) patients had Metacarpal, 3 (6.0%) patients had lesion in Post op both bone forearm, 3 (6.0%) patients had Post op intercondylar fracture humerus, 4 (8.0%) patients had Post op shaft femur, 3 (6.0%) patients had Post op shaft tibia, 6 (12.0%) patients had lesion in Shaft tibia. We demonstrated the microbiological profile, antibiogram pattern and clinical outcome in patients with suspected osteomyelitis, in a tertiary care hospital. The causative organism in chronic osteomyelitis was found to be related to the aetiology of the infection. Majority of haematogenous chronic osteomyelitis involved a solitary Gram-positive organism, most commonly Staphylococcus aureus. Incidence of Gram-negative infections were found to be higher than previously reported. Specially in post-traumatic and post-operative infections, Pseudomonas aeruginosa were commonly isolated. Resistance to broad spectrum Penicillin, third generation Cephalosporins and even Fluoroquinolones were higher than previously reported. Proper identification of the causative organism and antibiogram sensitivity testing plays a pivotal role in controlling the infection. With my study, we would be able to make a table of most appropriate antibiotics for suspected organisms according to the disease aetiology and it would help in starting the empirical therapy while the culture report arrives.
How to cite this article:
Tirthankar Pradhan and Sangeeta Ghosh. Analysis of Microbiological Profile, Antibiogram Pattern and Clinical Outcome in Patients with Suspected Osteomyelitis, in a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.18.581.586
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.18.581.586