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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Inguinal Lymph Node Density as a Predictor of Recurrence Free Survival and Overall Survival in Patients with Carcinoma Penis

Arnab Maity, Sudipta Kumar Singh, Shashikant Tewary, Partha Pratim Mondal and Ranjan Kumar Dey
Page: 577-580 | Received 24 May 2024, Published online: 23 Jun 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.2.18.577.580

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Abstract

The presence and degree of lymph node involvement is the primary prognostic factor for penile cancer, a severe urologic malignancy. Thus, inguinal lymph node dissection (ILND) has garnered a great deal of interest since it gives therapeutic benefit, useful pathologic staging and guidance for adjuvant treatment. To ascertain the relationship between LND and overall survival (OS) and recurrence free survival (RFS) in Ca Penis patients undergoing ILND at our institution. The present study was conducted from 2020-2023 at Department of Urology, RG KAR Medical College and Hospital, Kolkata, Patients with LND >20% had substantially poorer RFS and OS. [Median OS 65 months vs 12 months, p = 0.012; median RFS 47 months vs 10 months, p = 0.002]. LND was a statistically significant predictor of RFS in multivariate models including additional prognostic variables (hazard ratios of 4.41 and 3.82 for above and below the LND threshold, respectively). In conclusion, among patients with penile cancer, the density of inguinal lymph nodes is a major predictor of both overall survival and survival free of recurrence. The significance of a comprehensive evaluation of lymph nodes in the clinical treatment of penile cancer is highlighted by this discovery. Clinicians might possibly enhance patient outcomes by better stratifying risk, customizing treatment strategies and identifying patients with greater lymph node densities. In order to confirm these findings and provide more insight into the processes by which lymph node density affects survival outcomes in penile cancer, bigger cohort studies and longer follow-up periods are necessary.

How to cite this article:

Arnab Maity, Sudipta Kumar Singh, Shashikant Tewary, Partha Pratim Mondal and Ranjan Kumar Dey. Inguinal Lymph Node Density as a Predictor of Recurrence Free Survival and Overall Survival in Patients with Carcinoma Penis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.18.577.580
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.18.577.580