Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
166
Views
16
Downloads
A Comparative Evaluation of Dexmedetomidine and Fentanyl to Attenuate Haemodynamic Response to Laryngoscopy and Intubation: A Prospective Randomized Double‐Blind Study
Jagdishbhai G. Mer, Bhavesh B. Zinzala, Kishanbhai D. Shiyal and Jaldeep Patel
Page: 124-130 | Received 20 Nov 2023, Published online: 23 Dec 2023
Full Text Reference XML File PDF File
Abstract
The study aimed to conduct a comparative evaluation of the efficacy of dexmedetomidine and fentanyl in attenuating the hemodynamic response to laryngoscopy and intubation in patients undergoing elective surgeries. Laryngoscopy and intubation often induce sympathetic stimulation, leading to undesirable increases in heart rate (HR) and blood pressure. The impact of these drugs on mitigating these responses was systematically investigated to provide insights into their clinical utility. This prospective, double‐blind, randomized, study involved 100 participant with 1 and 2 of ASA grade undergoing elective surgeries under general anesthesia. Patients were randomly assigned to two groups, with one group receiving 1 mcg kg-1 dexmedetomidine and the other 2 mcg kg-1 fentanyl before induction. The study included rigorous monitoring of various hemodynamic parameters, such as HR, systolic and diastolic blood pressure and mean arterial pressure, at different time points during the perioperative period. Ethical committee approval and informed written consent were obtained. The baseline characteristics, including gender and age distribution, were comparable among the two groups. Dexmedetomidine (1 mcg kg-1) demonstrated superior efficacy in blunting the hemodynamic response compared to fentanyl at 2 mcg kg-1. Dexmedetomidine exhibited a significant reduction in HR at various time points after laryngoscopy and intubation compared to fentanyl. The systolic and diastolic blood pressure responses were also more effectively attenuated by dexmedetomidine. However, bradycardia was observed more frequently in the dexmedetomidine group. Intravenous administration of dexmedetomidine (1 mcg kg-1) proved more efficacious in attenuating the hemodynamic response to laryngoscopy and intubation, offering a favorable profile in terms of safety and recovery from anesthesia. In contrast, fentanyl at 2 mcg kg-1 demonstrated lesser efficacy in mitigating the pressor response. Both agents were considered safe for use in elective surgeries, providing valuable insights into their comparative utility in clinical practice.
How to cite this article:
Jagdishbhai G. Mer, Bhavesh B. Zinzala, Kishanbhai D. Shiyal and Jaldeep Patel. A Comparative Evaluation of Dexmedetomidine and Fentanyl to Attenuate Haemodynamic
Response to Laryngoscopy and Intubation: A Prospective Randomized Double‐Blind Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.124.130
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.124.130