Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Postoperative Analgesia with Intravenous Paracetamol and Fentanyl and Intravenous Fentanyl Alone in Patients Under Going Laparoscopic Cholecystectomy: A Prospective Randomized Double Blind Study
Rashmi Chaudhari, Darshana Kumbhre and Dipakkumar Ruparel
Page: 114-118 | Received 20 Nov 2023, Published online: 23 Dec 2023
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Abstract
The aim of our study was to determine the post‐operative analgesic effects of pre‐emptive intravenous (IV) Paracetamol and the amount of reduction in fentanyl requirement. After approval from institutional ethics committee, 60 patients of ASA PS I and II were enrolled and assigned to 2 groups of 30 each. Group I (fentanyl) and Group II(fentanyl plus Paracetamol) who received either an IV NS or an IV injection of 1g Paracetamol 10 min before induction. Induction and maintenance protocol was similar in both groups. Both groups received IM diclofenac 75 mg 8 hourly. The postoperative pain relief was evaluated by a visual analogue scale (VAS) every two hourly and fentanyl requirement as rescue analgesic in the postoperative period for 24 hrs after surgery was recorded. The incidence of complications including PONV and sedation scores was measured postoperatively. We recorded VAS score was comparable in postoperative period in both groups except during first and second hour of surgery in which group II(receiving paracetamol) was lower. (4.9±1 Vs3.2±0.5 and 4.1±0.3Vs 3.0±0.4) the fentanyl requirement over first 24 hrs was also less in the group II(receiving IV paracetamol) (70.16±43.65 Vs39.33±35.51). The time requirement of first dose of rescue analgesic in the postoperative period was also significantly prolonged in the group receiving IV paracetamol (79.37±64.32 Vs173.33±73.88). There was no difference in the sedation scores and in the incidence of PONV in the two groups. Preemptive iv paracetamol provided effective and reliable pain control after laparoscopic cholecystectomy reducing immediate post‐operative pain scores, decrease use of rescue opioid and the time to first request of analgesics.
How to cite this article:
Rashmi Chaudhari, Darshana Kumbhre and Dipakkumar Ruparel. Postoperative Analgesia with Intravenous Paracetamol and Fentanyl and Intravenous Fentanyl Alone in Patients Under Going Laparoscopic Cholecystectomy: A Prospective Randomized Double Blind Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.114.118
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.114.118