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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Prevalence and Clinical Manifestations of Vitamin B12 Deficiency Anemia in Adults: A Cross-sectional Study

Maulik Pradipbhai Panchal, Chintan Pravinchandra Patil, Karmarajsinh Dilipsinh Vaghela and Smithkumar Narendrakumar Modi
Page: 381-385 | Received 05 Oct 2024, Published online: 21 Sep 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.18.10.381.385

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Abstract

Vitamin B12 deficiency is a prevalent condition associated with various systemic manifestations, particularly among older people. The deficiency can arise due to inadequate dietary intake or impaired absorption, with sources of Vitamin B12 primarily being animal products. The study aims to explore the incidence, clinical manifestations and biochemical correlations of Vitamin B12 deficiency anaemia. The present research was conducted to determine the prevalence of Vitamin B12 deficiency anaemia in adults and to investigate its clinical manifestations and relation with other blood investigations. A hospital-based, cross-sectional study was conducted at a tertiary care centre. One hundred adult patients presenting with symptoms indicative of Vitamin B12 deficiency, such as tingling, giddiness and unsteady gait, were included. Laboratory investigations included Complete Blood Count (CBC), serum Vitamin B12 levels and other biochemical markers. Data analysis was performed using SPSS software, with chi-square tests for statistical significance (p<0.05). Out of 100 participants, 64% were diagnosed with Vitamin B12 deficiency anaemia. The highest incidence (32%) was in the 51-60 age group. Male patients comprised 52% of the study group. Giddiness (47%) was the most common symptom, followed by tingling (13%). Significant correlations were observed with mean corpuscular volume (MCV), platelet count and serum urea levels, while no significant association was found between Vitamin B12 deficiency and Vitamin D3 levels. Vitamin B12 deficiency anaemia is prevalent, especially in older people. Timely diagnosis and treatment can prevent irreversible damage and significant haematological parameters like MCV and platelet count are crucial in diagnosis.

How to cite this article:

Maulik Pradipbhai Panchal, Chintan Pravinchandra Patil, Karmarajsinh Dilipsinh Vaghela and Smithkumar Narendrakumar Modi. Prevalence and Clinical Manifestations of Vitamin B12 Deficiency Anemia in Adults: A Cross-sectional Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.18.10.381.385
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.18.10.381.385