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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Longitudinal Assessment of Oxidative Stress Biomarkers in Patients with Type 2 Diabetes: An Observational Study

G. Anil Kumar, T. Aruna Kumari, Thangella Kalyani and S. Apoorva
Page: 38-42 | Received 20 Jun 2023, Accepted 16 Aug 2023, Published online: 26 Sep 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.9.38.42

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Abstract

Oxidative stress plays a crucial role in the pathogenesis of Type 2 Diabetes (T2D) and its associated complications. This observational study aimed to investigate oxidative stress biomarkers in 100 patients with Type 2 diabetes (T2D) over a 12-month period. The study enrolled an equal number of males and females (50 each), with an average age of 57.4 years and an average T2D duration of 6.2 years. Oxidative stress was assessed at baseline, 6 months and 12 months. Malondialdehyde (MDA), a marker of lipid peroxidation, exhibited a significant increase from baseline (3.2±0.4) to 6 months (4.8±0.6, p<0.001) and 12 months (5.5±0.7, p<0.01), indicating progressive lipid peroxidation. Superoxide Dismutase (SOD) activity, an antioxidant enzyme, decreased from baseline (35.1±4.2) to 6 months (29.8±3.5, p<0.05) and further to 12 months (25.3±3.1, p<0.01), suggesting impaired antioxidant defense. Glutathione peroxidase (GPx) activity, another antioxidant enzyme, decreased from baseline (28.5±3.0) to 6 months (24.7±2.5, p<0.05) and 12 months (20.1±2.0, p<0.01), indicating compromised antioxidant capacity. Total antioxidant capacity (TAC) decreased from baseline (45.6±5.8) to 6 months (40.2±5.0, p<0.05) and 12 months (35.1±4.4, p<0.01), signifying a progressive reduction in overall antioxidant defense. In this cohort of T2D patients, oxidative stress biomarkers demonstrated adverse trends over 12 months. Increased MDA levels indicated heightened lipid peroxidation, while declining SOD, GPx and TAC levels suggested compromised antioxidant defense mechanisms. These findings emphasize the importance of managing oxidative stress in T2D patients to mitigate the risk of associated complications. Longitudinal monitoring and targeted interventions may be essential in improving oxidative balance and the overall health of T2D individuals

How to cite this article:

G. Anil Kumar, T. Aruna Kumari, Thangella Kalyani and S. Apoorva. Longitudinal Assessment of Oxidative Stress Biomarkers in Patients with Type 2 Diabetes: An Observational Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.9.38.42
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.9.38.42