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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Assessment of the Relationship Between Induced Sputum Eosinophil Count and Absolute Eosinophil Count as Indicators of the Severity of Bronchial Asthma

Puneet K Nagendra, Vinayakumar Jogondra, M. Kavitha, Santosh Honnavar and Harsha Hanji
Page: 822-828 | Received 22 Jul 2023, Published online: 08 Aug 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.822.828

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Abstract

Asthma stands as a prevalent significant non‐communicable ailment, profoundly affecting the quality of life for numerous individuals. On a global scale, asthma holds the 16th position among the primary contributors to years lived with disability and ranks 28th among the leading factors contributing to the overall burden of disease, as assessed through disability‐adjusted life years. This study aimed to establish a correlation between sputum and absolute eosinophil counts with asthma severity, FEV1 and other factors related to asthma. This prospective study was carried out in the department of respiratory medicine, Belagavi institute of medical sciences, Belagavi, Karnataka. Evaluation of asthma severity. The degree of asthma severity was evaluated following the guidelines set forth by GINA. This encompassed the following aspects asthma control questionnaire. This questionnaire encompassed the frequency of both daytime and nighttime symptoms the frequency of using short‐acting beta‐agonists and the extent to which daily activities were disrupted over the past 4 weeks. The relationship between absolute eosinophil count (AEC) and FEV1 was investigated in this study. When the AEC was between 301‐500 or greater than 500, there was a statistically significant relationship between the two variables. This suggests that higher AEC levels are associated with lower FEV1 values. For a sputum eosinophil count of less than 3%, there was no statistically significant relationship between the count and FEV1. However, when the count was between 3‐5%, there was some correlation but it was not statistically significant. For a sputum eosinophil count greater than 5%, there was a statistically significant relationship between the count and FEV1. Evaluating eosinophil levels in sputum and blood represents a straightforward and economical approach that directly quantifies airway inflammation. Consequently, this method holds the potential to pinpoint distinct phenotypes within asthmatic individuals who may exhibit heightened steroid responsiveness.

How to cite this article:

Puneet K Nagendra, Vinayakumar Jogondra, M. Kavitha, Santosh Honnavar and Harsha Hanji. Assessment of the Relationship Between Induced Sputum Eosinophil Count and Absolute Eosinophil Count as Indicators of the Severity of Bronchial Asthma.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.822.828
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.822.828