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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Prevalence and Treatment of Acid Peptic Disease in Patients with Sickle Cell Disease a Hospital Based Cross Sectional Study

Neha Banseria, Amit Jain, Manish Rathor and Hemant Kumar Jain
Page: 662-665 | Received 03 Jul 2023, Accepted 28 Jul 2023, Published online: 02 Aug 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.662.665

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Abstract

Sickle cell disease (SCD) is a chronic hemolytic disorder characterized by the presence of crescent‐shaped red blood cells. In adults with SCD, abdominal pain is a common presenting symptom. Among patients not in crisis, it is estimated that one‐third of individuals with homozygous SCD and chronic recurrent epigastric pain exhibit endoscopic evidence of peptic ulcer disease. This study aimed to analyze the incidence and management of acid peptic disorders among SCD patients in Central India. A prospective study was conducted, involving 68 homozygous SCD patients. All patients underwent upper gastrointestinal endoscopy (UGIE) with gastric antral biopsy and rapid urease test (RUT). Cases with Helicobacter pylori were administered a 14 days course of a three‐drug regimen of anti H. pylori drugs and were followed up for 6 weeks from the initiation of treatment with repeat UGIE and RUT. Out of the 68 cases, 14 cases (20.59%) were diagnosed with duodenal ulcer, which was significantly higher than the number of patients with gastric ulcer (11.76%). Other findings included gastroesophageal reflux disease and gastritis. Majority of patients tested negative for RUT after receiving anti H. pylori medication. SCD patients with acid peptic disorders form a considerable proportion of patients attending the surgical outpatient department and indoor department of surgery. Conservative treatment with lifestyle modification can effectively improve the symptoms of acid peptic disease.

How to cite this article:

Neha Banseria, Amit Jain, Manish Rathor and Hemant Kumar Jain. Prevalence and Treatment of Acid Peptic Disease in Patients with Sickle Cell Disease a Hospital Based Cross Sectional Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.662.665
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.662.665