Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Thalassemia causes varying degrees of anemia, which can range from significant to life threatening. People of Mediterranean, Middle Eastern, African and Southeast Asian descent are at higher risk of carrying the genes for thalassemia. Thalassemia causes varying degrees of anemia, which can range from significant to life threatening. India is a large Southeast Asian country with a population of over one Billion. An estimated 1‐3% of the population are carriers of beta thalassemia, a figure rising up to 17% in some ethnic groups. This is a prospective observational cohort study done in pediatric wards of two hospitals C.R. Gardi Hospital (C.R.G.H.) and associated hospitals from September 2016 may 2018. Main aim of this study is to study the hematological findings in Thalassemia major patients. Out of 60 patients of thalassemia were enrolled and their demographic hematological profile was taken. The mean age was 10.2 years, 75% were males and 81% were Hindus, 40% belonged to upper lower class. Most common clinical features were ( 97%) icterus followed by (90%) pallor, 80% of thalassemia patients had moderate to severe hepatomegaly. Mean Hb was 8.5±0.9 g dL-1, 67% had severe anemia, Mean MCV level was 73±2 μm3, Mean MCH and MCHC level were 20±2 pg cellG1, 28±2 gHb dL-1. Mean ferritin level was 1281.8±219.9 ng dL-1, 45% of thalassemic patients had serum ferritin level between 1000‐2000 ng dL-1 followed by 39% of patients had serum ferritin level more than 2500 ng dL-1, Mean frequency of blood transfusion 16±2 times a year, 55% of had blood transfusion 5‐10 times a year followed by 33% had frequency of blood transfusion 10‐15 times a year and only 12% had frequency more than 15 times a year, Mean interval between transfusion 22±2 days, 73% had an interval of 15‐25 days between two transfusion. According to 86% had euglycemia and 10% had hyperglycemia when blood sugar was tested randomly. About 90% of thalassemic patients had normal glucose tolerance test followed by 6.5% of thalassemic patients had impaired glucose tolerance test, while 3.3% patients came under diabetic range. About 81% of thalassemic patients had normal serum calcium level while 18% had hypocalcemia, 93% of thalassemic patients had normal serum T4 and TSH level, 1.6% of patients had subclinical hypothyroidism and only 4% of thalassemic patients had overt hypothyroidism. Tablet deferasirox was taken as chelating agent in all thalassemia patients, 51% of which were taking it after 2 years of age, 35% were had started between 1‐2 years of age and only 13% started below 1 year of age. The common adverse reaction in thalassemic patients were diarrhea (26.1%), abdominal pain (23%), skin rash (20%), seizures (16%), blurring of vision (3%).
How to cite this article:
Mohit Sharma, Shreya Shrivastava, Sunil Kumar Kasundriya and Amit Kumar Singh. Study the Hematological Finding in Thalassemia Major Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.521.529
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.521.529