Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Tuberculosis is one among the major health problems worldwide including our country, caused by Mycobacterium tuberculosis. There are many numbers of deaths occurring globally due to tuberculosis. According to Global TB report 2019, 10 million people were affected with TB, of these 7 million people were detected and officially notified. 1.6 million deaths were attributed to TB in 2018. To study the relationship of different resistant patterns among DR-TB patients with early treatment response i.e., proportion of culture conversion by the end of six months of treatment in terms of number of people converted and time taken for conversion in National Institute Of TB and Respiratory Diseases (NITRD) and factors affecting early culture conversion in MDR/PRE XDR/XDR TB patients. The present study was a Prospective Cross-sectional Observational study. This Study was conducted from January 2019 to October 2019 at Department of TB and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Diseases, New Delhi. In our study, majority of the DR TB patients were undernourished (BMI <18.5 kg m‾2). In the MDR group, the association between BMI and culture conversion in terms of time taken (<3 months) was not statistically significant (p>0.05). In our study 23/74 (31.1%) patients were smokers. Smokers were 9/25 (36%) among MDR, MDR FQ resistant cases 10/36 (26.4), none among MDR SLI resistant cases and 4/10 (44.4%) among XDR. There are very few studies on early culture conversion of MDR TB patients and even fewer in case of PRE XDR and XDR. Correlation of various factors with early culture conversion was made in MDR as well as PRE XDR and XDR patients in the sane study. Several reversible factors that influenced early treatment outcome were identified like BMI, anemia, hypoalbuminemia and correlated resistance pattern of ATT drugs with early culture conversion
How to cite this article:
Udvass Kumar Kotokey and Rupak Singla. To Study the Relationship of Different Resistant Patterns among MDR/PRE XDR (MDR +FQ/SLI)/XDR Patients with Early Treatment Response at NITRD.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.423.428
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.423.428