Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
This study aims to evaluate the effectiveness of serum fructosamine and glycated hemoglobin (HbA1C) as markers for assessing glycemic control and determining the severity and prognosis of chronic alcoholic liver disease. Specifically, it aims to identify the superior marker between HbA1C and fructosamine in this context. A total of 90 individuals, both male and female, aged between 20 and 70 years, diagnosed with chronic alcoholic liver disease, were included in the study. Additionally, 45 healthy individuals, matched for age and sex, served as controls. The patient group was further divided into non-complicated and complicated subgroups. HbA1C levels were measured using the immunoturbidimetry method, while serum fructosamine levels were determined using colorimetry with nitro blue tetrazolium. The estimation of SGOT was performed according to the IFCC method and serum total protein levels were assessed using the biuret method. In both groups of chronic alcoholic liver disease patients, the mean concentrations of HbA1c and serum total protein were decreased, while the mean concentrations of serum fructosamine and SGOT were increased. There was no significant difference in serum total protein between non-complicated cases and controls. The mean value of HbA1c did not differ significantly between non-complicated and complicated cases. SGOT exhibited a significant negative correlation with serum total protein, a significant positive correlation with serum fructosamine and no correlation with HbA1c. A significant negative correlation was found between serum total protein and serum fructosamine. The findings of this study indicate that serum fructosamine is a more effective marker for monitoring chronic glucose control and assessing the severity of chronic alcoholic liver disease in comparison to HbA1c.
How to cite this article:
Neha Banseria , P.J. Akshata , Rohan Dwivedi and Anjali Dubey. Assessment of HbA1C and Fructosamine in Alcoholic Liver Disease: A Case Control Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.130.134
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.130.134