Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
In our nation, neonatal septicaemia continues to be a leading cause of morbidity and mortality. About 30‐50% of all newborn deaths in underdeveloped nations are due to neonatal sepsis. Even though it poses a threat to life, if caught early enough, the illness is treatable. Even though it poses a threat to life, if caught early enough, the illness is treatable. Unfortunately, the initial symptoms and warning signals are sometimes vague and readily confused with those from noninfectious sources. The investigation was carried out in the pathology department of a tertiary care facility in Lucknow. All newborns who were suspected of having sepsis or who had a history of infection in their mothers were enrolled in the trial. Complete blood counts, CRP measures and a blood culture with antibiotic sensitivity were all part of the sepsis work‐up. A total leukocyte count (TLC), total neutrophil count (TNC) and platelet count were all included in the complete blood count. From the measured values, absolute neutrophil counts (ANC) were computed. The standard values were taken from Manroe values for the neonatal haematological markers. Prior to starting antibiotic therapy, blood samples were taken. The pathologist analysing the peripheral smear results was unaware of the newborn's infection status. Out of 150 newborns with possible sepsis were examined in total. Out of 150 clinically suspected cases, blood culture results showed that 60 neonates were septic and 90 neonates had probable sepsis. The gender distribution gap between the two groups was a significant finding. Males made up 50% of the group with suspected sepsis (n = 45), while females made up 50% of the group with proven sepsis (n = 60), with male newborns making up 60% (36/60) and female babies making up 40% (24/60). Preterm newborns made up 60% (54/90) of the group with suspected sepsis, compared to 70% (42/60) of the group with confirmed sepsis. The oldest was 41 weeks gestation and the youngest was 25 weeks. About 730‐4250 g were the range for birth weight. Although, the Hematologic profile that we looked at is a straightforward, efficient and affordable diagnostic for the early diagnosis of newborn sepsis, its sensitivity in that regard is subpar. Aseptic practises in delivery rooms and wards are essential for preventing conditions that lead to newborn septicemia, such as prematurity and low birth weight neonates. Antibiotic use should be justified and using antimicrobials according to the right protocols will lessen the threat of worldwide resistance development. As a result, it is unable to serve as a reference point for decisions on antibiotic therapy.
How to cite this article:
Pooja Agarwal. Role of the Hematological Profile in Early Diagnosis of Neonatal Sepsis in North India.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.113.117
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.113.117