Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
An orally disintegrating tablet (ODT) of Ondansetron offers an appealing option for preventing and managing post-operative nausea and vomiting (PONV) when compared to intravenous Ondansetron. This study aimed to establish that ODT Ondansetron is not inferior to intravenous Ondansetron in patients undergoing elective laparoscopic surgeries under general anaesthesia. Additionally, it sought to compare the need for rescue analgesics and the occurrence of complications between these two treatment groups. A prospective, randomized non-inferiority study was conducted with a cohort of 128 patients undergoing elective laparoscopic surgeries under general anaesthesia. These patients were randomly allocated into two groups, with 64 individuals in each. Group I received ODT Ondansetron 4mg sublingually half an hour before induction, while Group II received intravenous Ondansetron 4mg at the time of induction. PONV was assessed during two times. 0-6 hrs and 6-24 hrs post-surgery. Statistical analysis included an unpaired t-test to compare means and chi-square and Fisher’s exact tests to compare proportions. A p<0.05 was deemed statistically significant. Both groups of patients were similar in terms of baseline characteristics such as age, gender, type of procedures, ASA grades, PONV score, weight and duration of surgery. The difference in the requirement for rescue antiemetics between the two groups was not statistically significant. Likewise the incidence of complications was comparable between the two groups. The study concluded that ODT Ondansetron is non-inferior to intravenous Ondansetron in effectively preventing PONV.
How to cite this article:
Ajay B. Kalotra, Preksha Sharma, Akanksha Mishra and Smit Mehta. Sublingual Ondansetron vs. IV Ondansetron for Post-Operative Nausea in Laparoscopic Surgeries: A Non-Inferiority Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.96.100
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.96.100