files/journal/2022-09-03_18-51-40-000000_599.png

Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
About US
Editors
Issues
Pages
Indexed in
149
Views
10
Downloads

Screening of Adiponectin Gene +45 T/G Polymorphism in Central South Indian Population with and Without Type 2 Diabetis Mellitus Individuals

Krishnamoorthy Kasipalayam Murugan, Vanitha Kandasamy and Jayabal Arockiya Bharathi
Page: 206-210 | Received 01 Nov 2023, Published online: 30 Nov 2023

Download Citation
https://doi.org/10.36478/10.59218/makrjms.2023.11.206.210

Full Text Reference XML File PDF File

Abstract

Type 2 Diabetes Mellitus (DM) as a multifactorial complex disorder influenced by various genes and single nucleotide polymorphisms (SNP). The focus is on the Adiponectin (ADIPOQ) gene, significant in DM progression and treatment. The study aims to screen for allele and genotype frequencies of ADIPOQ 45 T/G polymorphisms in central Tamil Nadu, India, highlighting the novelty of this research in the region. Materials and The study setting at K.A.P.V. Government Medical College, Tamil Nadu, including ethical clearances and participant enrolment criteria. The method of blood sample collection, biochemical analysis and genotyping of SNP 45 T/G polymorphisms are elaborated, providing insights into the methodological rigour of the study. The statistical methods used are described, including the application of the SPSS program, student t-test, Chi-square test and logistic regression analysis. Emphasis is placed on the significance levels for evaluating the data. Results: The results section presents key findings, including the normal range of anthropometric parameters and clinical characteristics of the study individuals. It details the blood glucose levels, lipid profiles and genotypic frequencies observed in the study. Tables and figures supplement the data, offering a comprehensive view of the research outcomes. The conclusion emphasizes the importance of the G allele in the Adiponectin gene SNP+45 T/G polymorphism in increasing the likelihood of developing T2DM. It suggests that genotyping for this polymorphism can aid in early detection and management of T2DM, potentially leading to better therapeutic approaches targeting adiponectin receptors.

How to cite this article:

Krishnamoorthy Kasipalayam Murugan, Vanitha Kandasamy and Jayabal Arockiya Bharathi. Screening of Adiponectin Gene +45 T/G Polymorphism in Central South Indian Population with and Without Type 2 Diabetis Mellitus Individuals.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.206.210
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.206.210