Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Sepsis is a major cause of morbidity and mortality in children admitted in intensive care unit. Blood culture considered as a gold standard test for diagnosis of sepsis but C‐reactive protein (CRP) and procalcitonin (PCT) were the early diagnostic markers of sepsis. The objective of this study is to evaluate the serum CRP and PCT levels as reliable marker of sepsis in children. This cross sectional hospital based study conducted in the department of the paediatrics in a tertiary care hospital, central India. Children <16 years of age with clinically suspected sepsis was enrolled in this study. Patients were divided into two groups. Culture positive confirmed sepsis and culture negative probable sepsis. C.R.P. and P.C.T. level was measured in all the suspected patients. A total of 120 patients were enrolled of which 40 belonged to confirmed culture positive group and 80 were probable sepsis group. The mean age of the confirmed sepsis patients was 4.67±1.35, predominantly male children (60%). Longer duration of ICU stay significantly associated with the sepsis. Staph aureus was the most common isolated recovered from culture positive sepsis patients CRP and PCT levels were significantly higher in culture positive confirmed sepsis children as compared to culture negative probable sepsis children. Both CRP and PCT are highly effective diagnostic and prognostic markers of sepsis but PCT is earlier to rise and more reliable than CRP. Sepsis, CRP, PCT, sepsis markers, children.
How to cite this article:
Manish Rathore, Arpit Goel, Asheesh Gupta and Shashank Tyagi. Assessment of Procalcitonin and C‐Reactive Protein as a Sepsis Marker in Children.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.194.198
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.194.198