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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Histopathological Analysis and HER‐2/neu Expression in Endoscopic Guided Upper Gastrointestinal Biopsies: An Observational Study

Lavanya Ravutu, Sushma Jagadev, G. R. Sumanlata, Rema Nair Sarkar, Satyanarayana Rao Polisetty and C. V. Lakshmi
Page: 166-172 | Received 12 Nov 2023, Published online: 24 Nov 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.11.166.172

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Abstract

This study presents a comprehensive analysis of a cohort of 90 patients who underwent upper gastrointestinal endoscopic biopsies. The aim was to investigate the demographic characteristics and histopathological findings within the upper gastrointestinal tract. Demographic data, encompassing age and gender profiles, were systematically gathered for the entirety of the study cohort comprising 90 cases. Histopathological findings in the oesophagus, duodenum and stomach were documented, with a focus on both non‐neoplastic and neoplastic lesions. Additionally, the presence of HER‐2/neu over expression was assessed using immunohistochemistry (IHC) scores. The study found the most common age for upper gastrointestinal endoscopy patients to be 40‐60 years, with a nearly equal male‐to‐female ratio in esophageal biopsies and more males in duodenal and gastric biopsies. Esophageal biopsies often showed chronic esophagitis and Barrett’s oesophagus, while chronic duodenitis and inflammatory polyps were common in duodenal biopsies. Gastric biopsies typically revealed chronic gastritis, with well‐differentiated adenocarcinomas being the main neoplastic lesion. Gastric adenocarcinoma predominantly affected males in the 40‐60 year group, usually in the pyloric antrum and most lacked HER‐2/neu over expression. This study provides valuable insights into the prevalence and distribution of upper gastrointestinal lesions. The findings contribute to a better understanding of the demographic characteristics and histopathological features of these lesions, particularly in the context of gastric adenocarcinoma and HER‐2/neu expression. Our study findings play an important role in improving clinical management and treatment strategies for patients with upper gastrointestinal disorders.

How to cite this article:

Lavanya Ravutu, Sushma Jagadev, G. R. Sumanlata, Rema Nair Sarkar, Satyanarayana Rao Polisetty and C. V. Lakshmi. Histopathological Analysis and HER‐2/neu Expression in Endoscopic Guided Upper Gastrointestinal Biopsies: An Observational Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.166.172
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.166.172