Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Inflammation stands as an established pivotal factor in the pathogenesis of hypertension. C-reactive protein (CRP) is a recognized indicator of vascular inflammation linked to the development of hypertension. High-sensitivity CRP (hs-CRP) is a highly responsive marker for evaluating inflammatory changes even before the elevation of conventional CRP. The primary objective of this investigation was to discern the stage at which inflammation initiates in relation to the progression of hypertension, utilizing CRP and hs-CRP as biomarkers. This study employed a cross-sectional design, involving a cohort of 158 participants, categorized into three groups: Normotensive (n = 56), pre-hypertensive (n = 56) and hypertensive (n = 56) individuals. The classification of blood pressure was conducted in accordance with the Joint National Committee (JNC) guidelines. The analysis of hs-CRP was carried out employing the enzyme-linked immunosorbent assay (ELISA) method. A substantial disparity in hs-CRP levels was observed between the normotensive and hypertensive groups. Furthermore, a robust association was identified between hypertension, CRP and hs-CRP. High-sensitivity CRP emerges as a highly sensitive marker for the early assessment of inflammatory components in the context of hypertension.
How to cite this article:
Ishvarlal M. Parmar, Meghna Poonia, Ritu Sharma and Harshilkumar J. Shah. High-Sensitivity C-Reactive Protein as a Sensitive Indicator for Early Assessment of Inflammatory Factors in Hypertension.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.142.145
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.142.145