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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Evaluation of Paraoxonase 1 Activity: An Emerging Biomarker for Liver Function in Viral Hepatitis

Jyotchna D. Bade, Vydehi Veeramalla, M. Balachandra R. Naidu and Danturty L. Lalitha
Page: 137-141 | Received 21 Sep 2023, Accepted 24 Jul 2024, Published online: 15 Oct 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.11.137.141

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Abstract

The liver, a vital organ, plays a fundamental role in metabolism, detoxification and homeostasis maintenance. Effective diagnosis and management of liver diseases hinge on the accurate assessment of liver function using biochemical markers. This study aimed to evaluate the diagnostic efficiency of traditional and emerging liver function markers in distinguishing between viral hepatitis patients and controls. We analyzed liver parameters, including Total Bilirubin, Direct Bilirubin, AST, ALT, ALP, total proteins, albumin and PON1 in both viral hepatitis patients and control subjects. The study conducted ROC analysis to determine the sensitivity and specificity of these markers. Viral hepatitis patients exhibited significantly higher Mean±SD of total and direct bilirubin, AST, ALT and ALP compared to controls. Albumin levels and PON 1 activity were significantly lower in the viral hepatitis group. Total proteins did not demonstrate significant variability between the two groups. PON showed a negative correlation with several markers, with a significant negative correlation with AST. Total bilirubin showed strong positive correlations with direct bilirubin, total protein and albumin. The ROC analysis revealed PON 1's potential as a diagnostic tool with 100% sensitivity in detecting viral hepatitis. While traditional liver markers remain crucial for liver function assessment, emerging markers like PON1 provide complementary diagnostic insights. PON1's high sensitivity and specificity suggest its potential value in liver disease evaluations. However, further research is needed before its routine clinical adoption.

How to cite this article:

Jyotchna D. Bade, Vydehi Veeramalla, M. Balachandra R. Naidu and Danturty L. Lalitha. Evaluation of Paraoxonase 1 Activity: An Emerging Biomarker for Liver Function in Viral Hepatitis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.11.137.141
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.11.137.141