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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Evaluation of Safety and Efficacy of Ketamine Nebulization to Reduce Post‐operative Sore Throat in Patients Undergoing General Anesthesia‐Prospective Randomized Single Blind Placebo Controlled Study

Kiran Mulani, Lopa Trivedi, Meenu Sharma and Shruti Patel
Page: 111-115 | Received 25 Sep 2023, Published online: 08 Oct 2023

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https://doi.org/10.36478/10.59218/makrjms.2023.10.111.115

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Abstract

Postoperative sore throat (POST) affects between 21 to 65% of individuals. Ketamine, which was formerly used as a gargle to reduce POST, has limits. The purpose of this study was to determine whether nebulized ketamine lowers POST. A prospective, randomized, placebocontrolled, double‐blind study was carried out. 60 individuals with signed informed permission who were between the ages of 20 and 60 and of either sex and had physical status I‐II according to the American Society of Anesthesiologists were included. Patients were divided into two groups by randomization; group N got 5.0 mL of saline nebulization and group K received 1.0 mL of ketamine 50 mg along with 4.0 mL of saline nebulization for 15 min. Ten minutes after the patients' nebulization was finished, GA was induced. Prior to nebulization, before induction, at arrival in the post‐anesthesia care unit and at 2, 4, 6, 8 and 24 hrs after surgery, POST and hemodynamic monitoring were performed. On a scale from 0 to 3, POST received a grade. Incidence and severity of POST were significantly less in Group K as compared to Group N (p value<0.05) at 4, 6, 12 and 24th post operative hours. Hemodynamic parameters were comparable in both the groups. Ketamine nebulization significantly attenuated the incidence and severity of POST, especially in the early post operative period, with no adverse effects.

How to cite this article:

Kiran Mulani, Lopa Trivedi, Meenu Sharma and Shruti Patel. Evaluation of Safety and Efficacy of Ketamine Nebulization to Reduce Post‐operative Sore Throat in Patients Undergoing General Anesthesia‐Prospective Randomized Single Blind Placebo Controlled Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.10.111.115
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.10.111.115