Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Gastrointestinal stromal tumors (GIST) are mesenchymal tumors that arise from interstitial cells of Cajal in the gastrointestinal tract (GIT). They constitute about 0.2% of all gastrointestinal tumors. Even though effective chemotherapy has been developed, surgery remains the standard treatment for resectable tumors. GIST are rare GIT tumors. The main purpose is to evaluate various methods of management of GIST from our hospital. This manuscript aims to create awareness among General Surgeons regarding the workup and management of GIST in clinical practice. This is a retrospective analysis conducted in GIMSR, Visakhapatnam. All the cases diagnosed as GIST and managed in our institute from 1st February 2021 to January 30, 2023, were included in the study. After the clinical examination, the patients underwent endoscopy and imaging studies like the ultrasound Scan of the abdomen, CECT (Contrast Enhanced Computed Tomography) of the abdomen and immuno‐histo‐chemistry (IHC) studies. All patients who were diagnosed with the disease were subjected to excisional surgery as the primary modality of treatment except for the inoperable cases. Seven cases of GIST were managed in this study. Tumors were seen to arise from the stomach (4/7), ileum (2/7) and omentum (1/7). “The surgical management of these seven cases after complete workup included: resection and anastomosis of two cases of ileal tumors, wedge resection with adequate margin in two cases of stomach tumors, sleeve resection of the stomach in one case and omentectomy in one case along with the resection of the tumor had been done after investigations.” Chemotherapy was given to all deserving cases. GIST patients need CECT for accurate localization and operability. Immunohistochemistry study and Molecular genetic study should be done in all cases. Management of cases depends on site, size, operability, mitotic count and immunohistochemistry results. Each patient’s management should be individualized. CD117‐positive cases show a good response to chemotherapy. Follow‐up should be done once in six months.
How to cite this article:
J.N. Malleswara Rao, K. Punyavathi Poojitha, Syam Kumar Addepalli and Mohan Patro. Evaluation of Medical and Surgical Management of Gastrointestinal Stromal Tumors: A Retrospective
Analysis.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.10.10.17
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.10.10.17