Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
There is a close link between systemic inflammation, oxidative stress and dyslipidemia in increasing the frequency of CVD risk in psoriasis patients. Inspite of improvement in our knowledge on psoriasis from pathologic point of view the intimate mechanisms involving systemic inflammation, oxidative stress and dyslipidemia in psoriasis patients making them more susceptible to develop future CVD are complex and not yet fully understood. In the present study, 32 psoriasis patients were screened for active psoriasis (having more than 10% body area covered with severe psoriasis lesion) and 25 patients with active psoriasis (18 males and 7 females of 30‐50 years age group) were recruited (Group B). Age and sex matched 25 normal healthy volunteers do not have skin disorder were recruited as controls (Group A). P<0.05 and <0.001 were considered as significant and highly significant respectively. Plasma CRP and erythrocyte MDA levels were found to be significantly high (p<0.001, 41.02% and p<0.05, 29.4% high) in patient group as compared to healthy controls which reflect the role of inflammation and oxidative stress in disease process. Plasma lipid profile along with apolipoproteins levels, as depicted in Table 2 revealed that Plasma total cholesterol, triglycerides and LDL cholesterol levels were significantly high (p<0.05, 33.3%, 27.2% and 31.2% high) in patient group as compared to healthy controls. Life style modification, regular exercise and antioxidant rich diet should be incorporated along with prescribed drug for psoriasis treatment so that two important goal of CVD prevention i.e. maintenance of healthy lipid profile and regulation of inflammation along with oxidative stress can be easily achieved.
How to cite this article:
Khushboo Gupta. Assessment of Marker of Systemic Inflammation, Oxidative Stress and Plasma Lipid Profile in Psoriasis Patients.
DOI: https://doi.org/10.36478/10.59218/makrjms.2020.6.213.217
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2020.6.213.217