Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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The Diagnostic Utility of PAP Smear Cytology and Histopathological Correlation in the Cases of Cervical Carcinoma and Precancerous Cervical Lesion at Tertiary Center
Mital Kundariya, Meghavi Joshi, Kosha Panchal and Nikhil Anand
Page: 103-109 | Received 02 Mar 2023, Published online: 15 Jun 2023
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Abstract
Cervical carcinoma is one of the common cancer in indian female population. The cervical epithelial cells can exfoliate and a prolonged natural history of the pre-cancerous lesions is very helpful for the diagnosis of cervical carcinoma and pre-cancerous lesion. PAP smear is the very effective test to prevent and detect pre-cancerous lesion of the cervix before they become invasive cancer, However, false negative results may present due to sampling error or interpretation error. The confirmatory diagnosis should be made on histopathological examination and correlated for assessing the accuracy of the PAP smear cytology. (1) To study the importance of cytological (PAP smear) examination in cervical carcinoma and pre-cancerous lesio and (2) To study the histopathologcal correlation and Imunohistochemistry in cervical carcinoma and pre-cancerous lesion. Study of cases of cervical carcinoma and pre-cancerous lesion in which both PAP smear and histopathology samples were received during the period of 3 years. A detailed clinical history obtained from case files and records. The conventional PAP techniques using PAP stain, To eliminate subsampling and to obtain monodispersion of cells and clear background we used a newer technique-liquid based cytology by sure path method. Tissue samples were fixed, processed and stained with hematoxylin and eosin. In cases where needed further immunohistochemical markers were studied. Total 102 Cervical PAP test were examined and correlated with histopathological findings. In this study most of patients were of age group 40-59 year. Among the 102 cases, 66 (64.7%) patients were of postmenopausal age and there were 12, 8, 6, 23, 2 and 7 cases of ASCUS, ASC-H, LSILs, HSILs, AGC, AGUS, respectively. About 41 patients diagnosed as squamous cell carcinoma and 3 patients as adenocarcinoma. The histopathological examination of the specimen represented as follows: 6.86% CIN1, 1.96% CIN 2, 13.72% CIN3, 61.76% squamous cell carcinoma, 7.84% Adenocarcinoma and 7.84% were given false positive. Most of patients with cervical carcinoma and pre-cancerous lesions were in postmenopausal age. Multiparity is risk factor for cervical carcinoma. Squamous cell carcinoma of cervix was most common malignant lesion of cervix. PAP smear is an effective screening method for early diagnosis of pre-cancerous lesions and carcinoma of cervix so better awareness and motivation programs are recommended for prevention of cervical cancer. However, cervical biopsy is gold standard for accurate diagnosis and confirmation of cervical malignant lesions.
How to cite this article:
Mital Kundariya, Meghavi Joshi, Kosha Panchal and Nikhil Anand. The Diagnostic Utility of PAP Smear Cytology and Histopathological Correlation in the Cases of Cervical Carcinoma and Precancerous Cervical Lesion at Tertiary Center.
DOI: https://doi.org/10.36478/10.59218\makrjms.2023.103.109
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218\makrjms.2023.103.109