Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Hypothyroidism is a condition characterized by insufficient production of thyroid hormones, which are crucial for metabolic and neurological functions. CNS involvement in hypothyroidism arises due to decreased availability of thyroid hormones, which affects brain metabolism and neuronal signalling. Thyroid hormones regulate myelination, neuronal migration, and synaptogenesis, making hypothyroidism particularly impactful in developmental stages. Common neurological symptoms include fatigue, depression, memory impairment, and difficulty concentration. Severe hypothyroidism may lead to myxoedema, which can cause altered mental status, stupor, or coma in extreme cases. In untreated congenital hypothyroidism, CNS effects may result in intellectual disabilities or delayed developmental milestones. Treatment with levothyroxine typically alleviates CNS symptoms, although recovery may be gradual, depending on the duration of untreated hypothyroidism. Early diagnosis and treatment are critical to prevent irreversible CNS damage and to restore normal neurological function. Thyroid hormone is having direct effect on the electroencephalogram in regard to configuration, frequency and evoked responses. In the previous studies It has been stated that a slowing of dominant rhythm and reduction in amplitude of the EEG background activity, and reduced photic driving can be seen in approximately one-third of hypothyroid patients which may be reversible with treatment. In addition, a decrease in stages 3 and 4 sleeps has been reported in hypothyroidism. To compare the changes of Electroencephalographic activity in hypothyroid individuals and euthyroid individuals. A total of 60 individuals aged 20-50 years participated in this study, divided into two groups as 30 cases and 30 controls. History, demographic details is collected using questionnaires and face-to-face interviews. Anthropometric measures was measured and BMI was calculated. Electroencephalographic recording was conducted in Research Laboratory, Department of Physiology, Tirunelveli medical College, Tirunelveli. After getting written consent from the participants, they were taken to Research laboratory, Department of Physiology between 10 am-1 pm. EEG was recorded in all the individuals and recordings were compared between cases and controls. The association between hypothyroid and EEG waves were found in this study. Results were assessed by using SPSS software 23 version. Using this software mean standard deviation, p values were calculated, unpaired t test was used for analysis, p value less than 0.05 was considered significant. This study concludes that hypothyroidism is significantly correlated with CNS manifestation and highlighting the role of thyroid hormones for normal functioning of brain.
How to cite this article:
R. Vijayalakshmi, M. Anita, H.R. Haribabu and M. Shabiha. A Comparative Study of Eeg Changes in Hypothyroid Individuals and Euthyroid Individuals.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.67.71
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.67.71