Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Lactate clearance is recognized as a significant prognostic marker in sepsis, reflecting the effectiveness of resuscitative efforts and the restoration of tissue perfusion. The ability to predict outcomes based on lactate clearance rates could greatly enhance clinical decision‐making in managing septic shock. This cross‐sectional study involved 200 patients diagnosed with septic shock at a tertiary care hospital. Lactate levels were measured upon admission and at 6, 12 and 24 hours post‐admission. Lactate clearance was calculated as the percentage decrease in lactate levels over these intervals. The primary outcome was mortality, analyzed in relation to lactate clearance rates using logistic regression to adjust for potential confounders. The study found a significant inverse relationship between lactate clearance rates and mortality. Patients with a lactate clearance rate of less than 10% within the first 24 hours had the highest mortality rate (61.3%), whereas those with clearance rates exceeding 20% had significantly lower mortality rates (29.2%). Statistical analyses confirmed the robustness of these findings (p<0.05 across all groups). Lactate clearance within the first 24 hours of intensive care unit admission is a strong predictor of mortality in patients with septic shock. Higher lactate clearance rates are associated with lower mortality, highlighting the importance of rapid lactate normalization as a goal in sepsis management. These findings support the integration of lactate clearance monitoring into routine clinical protocols for patients with septic shock.
How to cite this article:
Allauddin , S. Saddam Hussain and Tanveer Ahmed. Role of Lactate Clearance in Predicting Mortality in Patients with Septic Shock: A Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.324.328
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.324.328