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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Study to Assess Diagnostic Accuracy of Procalcitonin in Differentiating Gram Negative from Gram Positive Blood Stream Infections in Critically ill Patients Admitted to ICU

K. Kiran, Ahemer Siddiqui, K.S. Supritha, Mahesh koulagi and Akshay Biskop
Page: 238-242 | Received 20 Nov 2024, Published online: 23 Jan 2025

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https://doi.org/10.36478/10.36478/makrjms.2025.2.238.242

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Abstract

Serum procalcitonin (PCT) levels differ in patients with bacterial infections and are significantly elevated in patients with Gram‐negative bacteremia. In this study we aimed evaluation of diagnostic accuracy of inflammatory markers ( PCT and CRP) to establish sepsis caused by different pathogens. Present study was aimed to determine the efficacy and accuracy of procalcitonin to differentiate Gram‐negative bacteria from Gram‐positive bacteria in blood stream infections. 100 Cases for study group were selected from patients admitted to medical wards. Patients included in the study group were subjected to through clinical evaluation in terms of history, clinical examination and relevant investigations so as to assess the causes of the bloodstream infections. The clinical profile of 100 patients with sepsis was studied. Study group included 60 male and 40 female patients. The mean procalcitonin was 0.8 and 6.1 ng/dl in gram positive and gram negative bacteria respectively (P<0.001). ROC analysis revealed an optimal cut‐off value of 2.3 ng/mL for PCT in discriminating Gram‐negative from Gram‐positive sepsis. Serum PCT levels were higher in patients with Gram‐negative sepsis than in Gram‐positive sepsis. PCT is a sensitive biomarker that can be used to distinguish Gram‐negative from Gram‐positive sepsis.

How to cite this article:

K. Kiran, Ahemer Siddiqui, K.S. Supritha, Mahesh koulagi and Akshay Biskop. A Study to Assess Diagnostic Accuracy of Procalcitonin in Differentiating Gram Negative from Gram Positive Blood Stream Infections in Critically ill Patients Admitted to ICU.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.238.242
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.238.242