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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Serum Lactate, Ferritin, Albumin and Oxidative Stress Markers as Diagnostic and Pathophysiological Indicators in Chronic Rhino Sinusitis

P. Balaji, M. Bhaskara Rao, S. Agni Vishnu Sailesh and K. Kalyan Kumar
Page: 141-145 | Received 20 Aug 2024, Published online: 18 Jan 2025

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https://doi.org/10.36478/10.36478/makrjms.2025.2.141.145

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Abstract

Chronic Rhino sinusitis (CRS) is a multi factorial inflammatory disorder characterized by persistent sinonasal symptoms that significantly impact patients' quality of life. Identifying reliable systemic biomarkers and oxidative stress markers is crucial for improving CRS diagnosis, monitoring and management. To evaluate the role of serum lactate, ferritin and albumin as biomarkers and oxidative stress markers (MDA, SOD, GPx and ROS) in CRS, elucidating their association with disease severity and systemic inflammation. A cross‐sectional study was conducted at the Departments of ENT and Biochemistry, Mamata Medical College, Khammam. A total of 100 patients aged 18‐65 years diagnosed with CRS (with or without nasal polyps) were included. Serum lactate, ferritin and albumin levels were measured using standard biochemical methods. Oxidative stress markers (MDA, SOD, GPx and ROS) were assessed. CRS severity was evaluated using the Visual Analog Scale (VAS) and Lund‐Mackay scoring on CT imaging. Statistical analysis was performed to assess correlations between biomarkers and disease severity. The study included 100 participants (mean age: 40 years, SD: 12., 60% male, 40% female). Serum biomarkers showed mean albumin levels of 4.01 g/dL, lactate 2.44mmol/L and ferritin 151.11ng/mL, indicating systemic inflammation and metabolic disturbances. Oxidative stress markers, including MDA (2.59nmol/mL), SOD (91.23U/mL), GPx (6.85 U/mL) and ROS (18.90 arbitrary units), were elevated, correlating with CRS severity. Mean severity scores were 6.71 (VAS, SD: 2.17) and 11.71 (Lund‐Mackay, SD: 3.16), highlighting the link between inflammation, oxidative stress and symptom severity. This study highlights the potential of serum lactate, ferritin and albumin levels, alongside oxidative stress markers, as systemic indicators of inflammation and oxidative damage in CRS. These biomarkers can aid in assessing disease severity, contributing to improved diagnostic precision and personalized treatment strategies. Further research with larger cohorts and longitudinal designs is warranted to validate these findings.

How to cite this article:

P. Balaji, M. Bhaskara Rao, S. Agni Vishnu Sailesh and K. Kalyan Kumar. Serum Lactate, Ferritin, Albumin and Oxidative Stress Markers as Diagnostic and Pathophysiological Indicators in Chronic Rhino Sinusitis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.141.145
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.141.145