Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Chronic periodontitis is a prevalent inflammatory condition that has been linked to various systemic diseases, including metabolic syndrome. This review aims to synthesize evidence on the impact of chronic periodontitis on systemic inflammatory markers in patients with metabolic syndrome, exploring the potential for periodontal therapy to modulate these markers. We conducted a comprehensive review of studies that measured systemic inflammatory markers (CRP, IL‐6, TNF‐a) in patients with both chronic periodontitis and metabolic syndrome. Relevant databases were searched for studies published up to 2023 and both cross‐sectional and longitudinal studies were included. The review found that patients with chronic periodontitis and metabolic syndrome exhibit significantly higher levels of systemic inflammatory markers compared to controls without periodontitis. Interventional studies highlighted that periodontal therapy could significantly reduce levels of CRP, IL‐6 and TNF‐a in these patients. The mechanisms proposed include reduction in systemic bacterial load and modulation of inflammatory pathways. Chronic periodontitis contributes to the elevated systemic inflammatory profile in patients with metabolic syndrome. Periodontal therapy not only improves oral health but also appears to reduce systemic inflammation, suggesting a potentially vital role in managing metabolic syndrome. Further research into specific biological pathways and long‐term outcomes of periodontal treatment is warranted to strengthen these findings.
How to cite this article:
Krishna R. Suryawanshi, Santosh Martande, Darshan N. Kalal, D. Gopalakrishnan and Rajkumar I. Suryawanshi. Impact of Chronic Periodontitis on Systemic Inflammatory Markers in Metabolic Syndrome.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.2.126.131
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.2.126.131