Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
94
Views
4
Downloads
Abstract
Acne vulgaris is a common skin condition affecting adolescents and young adults, often requiring systemic treatment for moderate to severe cases. Oral isotretinoin is a highly effective therapy, traditionally administered daily, but concerns over side effects like dryness and liver toxicity have prompted interest in alternative dosing strategies. Intermittent dosing, where isotretinoin is given at intervals rather than daily, has been proposed as a safer option with similar efficacy. This study aims to assess the efficacy and safety of intermittent oral isotretinoin in the management of acne vulgaris, comparing it to the traditional daily regimen. To evaluate the clinical efficacy of intermittent dose Isotretinoin regimens in acne vulgaris using Global acne grading system (GAGS). A prospective observational study in which 30 patients with acne vulgaris were assessed clinically using Global acne grading system(GAGS). Intermittent dose of Isotretinoin was administered as 0.5 mg/kg/day on alternate days. The Patients were reviewed on a monthly basis and any instances where no additional lesions were observed were documented. We identified 30 patients with Acne vulgaris and were given intermittent dose of isotretinoin. The mean acne scores were compared after completion of treatment, it was observed that, a significant decrease in the mean scores from 119.04±7.07‐12.5±1.64 among the patients was seen. This difference was found to be statistically significant. Patient satisfaction levels was about excellent response in 60% of patients. Intermittent isotretinoin dosing a promising alternative to the conventional daily regimen for treating acne, particularly for mild to moderate cases. This approach effectively reduces acne severity while minimizing mucocutaneous side effects. Given its reduced side effect and improved patient adherence, intermittent dosing may be a preferred treatment strategy, especially for those who struggle with the adverse effects of standard isotretinoin therapy.
How to cite this article:
D.V. Praveen Kumar Raju, Ramala Amala, T. Nirupama Bhagyalakshmi and Duvvuru Lakshmi Sowmya. A Study on Efficacy of Intermittent Dose of Oral Isotretinoin in the Management of Acne Vulgaris.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.527.530
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.527.530