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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Study to Assess the Association Between Hypocortisolemia and Mortality Among Patients Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital in Central Kerala

Merlin Elizabath Thomas, M.V. Merly, Parvathi Vijayadharan, V. Abhishek, A. Vishnupriya, Amal Joseph, Anna Carin Sunil, Athul Pratheesh George Poothavelil, Edwin J. George and Geeta Panicker
Page: 500-504 | Received 25 Nov 2024, Published online: 08 Jan 2025

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https://doi.org/10.36478/10.36478/makrjms.2025.1.500.504

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Abstract

Hypocortisolemia is a common complication that we come across in critically ill patients. Hence earlier diagnosis and adequate identification of this complication is warranted for planning early intervention. A cross sectional study was conducted among patients admitted in medical ICU under the Department of General Medicine, Amala Institute of Medical Sciences, Thrissur for a period of one year from March 2021 to February 2022. Consecutive consenting 231 patients were included in the study. Random serum cortisol level was assessed within 24 hours of admission to medical ICU. Patients with random serum cortisol level <15μg/dl were considered to have hypocortisolemia, those with value between 15μg/dl‐34μg/dl were considered as normal and those patients with cortisol level >34μg/dl were considered to have hyper cortisolemia. Q‐SOFA scoring was performed to assess the severity of illness. The requirement of vasopressors among the study population was noted. Patients were followed until the time of discharge from or death in medical ICU. The proportion of hypocortisolemia in patients admitted to medical intensive care unit was 31.4%. The critically ill patients amongst the study population were found to have a significant association with low cortisol levels. The mean age of mortality was found to be 65.71 years. However, no significant association could be established between hypocortisolemia and mortality among patients admitted to the medical intensive care units. Our study concluded that even though there was a significant association between critically ill patients and those requiring a longer hospital stay with hypocortisolemia, there was no significant association between hypocortisolemia and mortality among patients admitted in ICU.

How to cite this article:

Merlin Elizabath Thomas, M.V. Merly, Parvathi Vijayadharan, V. Abhishek, A. Vishnupriya, Amal Joseph, Anna Carin Sunil, Athul Pratheesh George Poothavelil, Edwin J. George and Geeta Panicker. A Study to Assess the Association Between Hypocortisolemia and Mortality Among Patients Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital in Central Kerala.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.500.504
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.500.504