Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Allergic rhinitis (AR) is a common disorder that affects people of all ages and is associated with significant impairments in quality of life, sleep and work performance. The prevalence of AR is approximately 10‐40%, 1 in 6 individuals are affected by allergic rhinitis across the globe. A total of 64 patients attending the outpatient section of Otorhinolaryngology department, diagnosed with persistent moderate‐severe allergic rhinitis as per ARIA guidelines, fulfilling the inclusion and exclusion criteria were included in this study. The patients were randomly assigned to two groups of 32 patients each. After the initiation of the therapy, patients were followed up at 2 weeks, 4 weeks and 8 weeks. The mean age of the test group was 28.06±8.4 years, while the control group's mean age was significantly higher at 34.62±8.3 years, with a P value of 0.006 indicating a significant difference. The gender distribution between the test and control groups was not significantly different. The distribution of most common allergens showed similar trends between the test and control groups. The most common allergen was Dermatophagoides farinae. The mean TNSS score before therapy in the test group was 8.09±1.532, which significantly reduced to 4.25±1.524 after therapy while in the control group, it decreased from 7.81±1.148 before therapy to 6.66±1.516 after therapy. In the test group, the mean IL‐4 declined by 20.39% after therapy while the mean IL‐13 level showed 9.48% reduction. On the other hand, in the control group both mean IL‐4 and IL‐13 levels slightly increased. The significant decrease in IL‐4 and IL‐13 levels in test group as compared to control group indicate that the therapy was effective in study subjects. Thus, we can conclude that antioxidants may play a major role in the prevention and treatment of AR. However more studies with a larger sample size are needed to further confirm these findings.
How to cite this article:
Juhaina Iqbal, Seema Monga, Deepti Agarwal, Shahid Rasool and Kailash Chandra. Assessment of Change in Cytokine and Chemokine Profile with Antioxidant Therapy in Allergic Rhinitis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.444.450
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.444.450