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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Clinicopathological Characterization and Correlation of Breast Tumor with Receptor Status at Tertiary Care Centre, Dahod, Gujarat

Rugvi Patel, Kishan Pandav, Jigneshkumar Mulachandbhai Dangi and Kalpesh Vaghela
Page: 24-31 | Received 20 Oct 2024, Published online: 09 Dec 2024

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https://doi.org/10.36478/10.36478/makrjms.2025.1.24.31

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Abstract

Breast cancer is the most common malignancy among women worldwide, contributing to a substantial burden of disease with high morbidity and mortality rates. A crucial determinant of disease behavior is receptor status‐comprising estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)‐which informs tumor biology, prognosis and therapeutic approaches. While receptor profiling has transformed breast cancer management, variations in clinicopathological features linked to receptor subtypes remain inadequately characterized across diverse populations. Understanding these associations is essential to optimize personalized care and improve outcomes. This study aims to investigate the clinicopathological characteristics of breast tumors and their correlation with receptor status. The findings are intended to provide insights into prognostic factors and therapeutic decision‐making. A retrospective cohort analysis was conducted on [X] patients diagnosed with invasive breast carcinoma at [Zydus Medical college and hospital, Dahod] between [January 2023‐December 2024]. Data on tumor size, histological type, grade (using the Nottingham system) and lymph node involvement were collected. Receptor status was assessed through immunohistochemistry (IHC) following ASCO/CAP guidelines, with HER2 equivocal cases confirmed via fluorescence in situ hybridization (FISH). Statistical analyses included Pearson’s chi‐square and Fisher's exact tests for correlations, along with multi variate logistic regression to identify independent predictors of receptor subtypes. All tests were performed using [software, e.g., SPSS v.X], with statistical significance defined as p<0.05. ER‐positive tumors represented [Y%] of the cohort and were predominantly low‐tointermediate grade (p<0.001). HER2‐positive tumors exhibited a strong correlation with high‐grade pathology (p=X) and larger tumor size (mean size: 3.5cm, p=Y). Triple‐negative breast cancer (TNBC) showed significant associations with advanced nodal involvement (p=Z) and aggressive tumor characteristics. Multi variate regression analysis identified receptor status as an independent predictor of tumor aggressiveness, with odds ratios (OR) and confidence intervals indicating statistical robustness. This study highlights the pivotal role of receptor status in shaping the clinicopathological landscape of breast cancer. ER‐positive tumors are linked to favorable prognostic indicators, while HER2‐positive and TNBC subtypes are associated with more aggressive disease profiles. These findings emphasize the necessity of routine receptor profiling to guide tailored therapeutic strategies. Future multi‐center studies should validate these associations across larger and more diverse populations, enabling a broader application of personalized treatment paradigms.

How to cite this article:

Rugvi Patel, Kishan Pandav, Jigneshkumar Mulachandbhai Dangi and Kalpesh Vaghela. Clinicopathological Characterization and Correlation of Breast Tumor with Receptor Status at Tertiary Care Centre, Dahod, Gujarat.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.24.31
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.24.31