Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Deciphering the Impact of Dengue Serotypes on Liver Function Tests (LFTs), Kidney Function Tests (KFTs) and Complete Blood Counts (CBC): A Comprehensive Analysis
Pradeep Kumar Gupta, Neha Tiwari, Vishal Agrawal, Sunit Kumar Sachan, Shiva Kumar and Sachin Ranjan
Page: 212-223 | Received 25 Sep 2024, Accepted 20 Dec 2024, Published online: 20 Dec 2024
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Abstract
The primary aim of this review article is to elucidate the differential impacts of dengue serotypes on liver function tests (LFTs), kidney function tests (KFTs), and complete blood counts (CBC) through a comprehensive analysis of existing literature. By doing so, it seeks to enhance the understanding of dengue's pathophysiology and inform more targeted clinical management strategies. This review systematically searched and analyzed peer-reviewed studies, meta analyses, and case reports from databases such as PubMed, Scopus, and Web of Science. The inclusion criteria focused on studies that explicitly examined the relationship between dengue serotypes and alterations in LFTs, KFTs, and CBC parameters. Data were synthesized qualitatively, highlighting patterns of organ involvement across different serotypes. All dengue serotypes were associated with some degree of liver impairment, as evidenced by elevated levels of AST and ALT. Serotype-specific patterns were less clear, though some studies suggested DENV-2 might cause more significant liver enzyme elevations. Kidney function impairment was less commonly reported but tended to be more severe with DENV-3 and DENV-4, with cases of acute kidney injury requiring dialysis. Thrombocytopenia was a universal finding across all serotypes, while leukopenia was more pronounced with DENV-1 and DENV-3. Hematocrit levels were often elevated, indicating hemoconcentration. The review highlights the need for clinicians to consider the potential for differential organ involvement based on the dengue serotype, which can influence management strategies, especially in regions where multiple serotypes circulate. It also underscores the importance of further research into serotype-specific pathophysiological mechanisms to improve patient outcomes. Additionally, the findings advocate for the development of rapid serotyping methods in clinical settings to refine prognosis and tailor supportive treatments more effectively.
How to cite this article:
Pradeep Kumar Gupta, Neha Tiwari, Vishal Agrawal, Sunit Kumar Sachan, Shiva Kumar and Sachin Ranjan. Deciphering the Impact of Dengue Serotypes on Liver Function Tests (LFTs), Kidney Function Tests (KFTs) and Complete Blood Counts (CBC): A Comprehensive Analysis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.212.223
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.212.223