files/journal/2022-09-03_18-51-40-000000_599.png

Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
About US
Editors
Issues
Pages
Indexed in
100
Views
8
Downloads

Role of Tranexamic Acid to Reduce Blood Loss at the Time of Placental Separation and Immediate Postoperative Period in Cesarean Deliveries: A Double Blinded Randomised Controlled Trial

Hina , Puneeta Mahajan, Aditya Vikram, Shikha Chadha and Mansi Kumar
Page: 188-193 | Received 15 Nov 2024, Published online: 19 Dec 2024

Download Citation
https://doi.org/10.36478/10.36478/makrjms.2025.1.188.193

Full Text Reference XML File PDF File

Abstract

Postpartum hemorrhage is a leading cause of maternal morbidity and mortality worldwide. Tranexamic acid has been shown to reduce blood loss in various surgical settings, but its efficacy in cesarean deliveries remains unclear. To evaluate the efficacy of prophylactic tranexamic acid in reducing blood loss and related complications in patients undergoing cesarean delivery. A randomized, double‐blinded, controlled study was conducted on 200 term pregnant women undergoing cesarean delivery. Participants were randomly allocated to receive either tranexamic acid (n=100) or placebo (n=100). The primary outcome was total blood loss, and secondary outcomes included the incidence of postpartum hemorrhage and the need for additional interventions to control blood loss. The mean total blood loss was significantly lower in the tranexamic acid group (462.89±142.21 mL) compared to the control group (599.26±221.66 mL, P<0.0001). The incidence of postpartum hemorrhage was also significantly lower in the tranexamic acid group (4% vs. 15%, P=0.0081). The tranexamic acid group required fewer additional interventions, including uterotonics (12% vs. 26%, P=0.0118), blood transfusions (7% vs. 21%, P=0.0044) and surgical interventions (6% vs. 14%, P=0.0600). Prophylactic administration of tranexamic acid significantly reduces total blood loss, the incidence of postpartum hemorrhage and the need for additional interventions in patients undergoing cesarean delivery. This intervention may improve maternal outcomes and decrease healthcare costs associated with the management of postpartum hemorrhage.

How to cite this article:

Hina , Puneeta Mahajan, Aditya Vikram, Shikha Chadha and Mansi Kumar. Role of Tranexamic Acid to Reduce Blood Loss at the Time of Placental Separation and Immediate Postoperative Period in Cesarean Deliveries: A Double Blinded Randomised Controlled Trial.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.188.193
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.188.193