Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The prevalence and pattern of endocrine disorders among individuals with traumatic brain injury (TBI) has been the subject of very few investigations. This study was meant to investigate the pattern of endocrine disruption following a severe head injury. Severe head injury patients admitted to the Department of Neurosurgery, Government Medical College and Government General Hospital, Mahabubabad, from June 2023 to May 2024 in 12 months duration of study. All patients underwent NCCT of the skull upon admission, in addition to a clinical assessment. We conducted a comprehensive anterior pituitary hormone investigation after 24 hours of damage and repeated it at 2 weeks, 3 months and 6 months for the patients who survived. A total of 50 patients were included in the study. Forty of our patients succumbed in the hospital. Rest of the patients were followed up for 6 months. Elevations of cortisol followed by prolactin were the most common hormonal derangements at admission. On CT images, the midline shift was negatively associated with cortisol elevation and directly related to GH increase. On CT scans, infarcts were negatively associated with increases in cortisol and LH. A significant change was identified in the declining trend of the mean T4 values and normalization, or a decreasing tendency from initially increased mean cortisol and GH levels over follow‐up (p<0.05). This study demonstrates that alterations in hormone profiles appear to be quite prevalent in severe TBI and fluctuate dramatically over at least 6 months., there is a link between age and radiological results. Performance of hormonal analysis evaluation should be addressed in patients with severe brain damage so that adequate hormone replacement may be done to optimize the clinical outcome.
How to cite this article:
Raghupathi Oruganti, Sricharan Mittapally and Boragala Rajamohan. A Prospective Study: Assessment of Endocrine Abnormalities in Severe Traumatic Brain Injury.
DOI: https://doi.org/10.36478/10.36478/makrjms.2025.1.173.178
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2025.1.173.178