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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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IHC Profile of Lung Tumors in Core Biopsies at Tertiary Care Centre in Kanyakumari District

Sreeja K. Bhasy, Evelyn Angel, Veer Dinesh, Ashwathy Senan, Monica Tefilah, Roselin Samuel and Anisha Shaheen
Page: 384-388 | Received 17 Feb 2024, Published online: 16 Mar 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.2.384.388

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Abstract

Lung cancer is one of the leading causes of cancer‐related mortality worldwide. Immunohistochemistry (IHC) plays a crucial role in the diagnosis and classification of lung tumors, which is essential for guiding treatment strategies. This study aims to evaluate the IHC profile of lung tumors in core biopsies at a tertiary care center in Kanyakumari District. A retrospective study was conducted using medical records of patients diagnosed with lung tumors based on core biopsy samples at the tertiary care center from January 2018 to December 2022. Data were collected on demographics, tumor characteristics, and IHC markers. Statistical analyses were performed to determine the prevalence and patterns of IHC marker expression. The study included 150 patients diagnosed with lung tumors. The most common histological subtype was adenocarcinoma (55%), followed by squamous cell carcinoma (30%) and small cell lung cancer (15%). The prevalence of key IHC markers such as TTF‐1, Napsin A, p40, CK5/6 and Ki‐67 varied across different subtypes. Significant associations were identified between IHC marker expression and tumor characteristics, including histological subtype, tumor grade, and stage. The findings highlight the importance of IHC profiling in the accurate diagnosis and management of lung cancer. This study underscores the significant variability in IHC marker expression among lung tumors. Routine evaluation of IHC markers is essential for accurate diagnosis, classification and personalized treatment planning. Further research is needed to explore the clinical implications of these findings in the regional context.

How to cite this article:

Sreeja K. Bhasy, Evelyn Angel, Veer Dinesh, Ashwathy Senan, Monica Tefilah, Roselin Samuel and Anisha Shaheen. IHC Profile of Lung Tumors in Core Biopsies at Tertiary Care Centre in Kanyakumari District.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.2.384.388
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.2.384.388