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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Randomized Control Trial of Two Doses of Pregabalin as a Premedication for General Anaesthesia in Major Abdominal Surgeries and it’s Fentanyl Sparing Effect in a Tertiary Care Hospital

Sheikh Monazzam Hossain, Sritam Mohanty, Bani Parvati Magda Hembrom and Divya Chandra
Page: 141-147 | Received 20 Nov 2023, Published online: 23 Dec 2023

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https://doi.org/10.36478/10.36478/makrjms.2024.2.141.147

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Abstract

Preoperative sedation and cardiovascular stability along with the reduction of pain perception during induction, laryngoscopy and intubation in general anesthesia and throughout the surgical procedure and postoperative period is the most essential part of anesthesia practice for better patient outcome. Present study was aimed to compare two doses of pregabalin as a premedication for general anaesthesia in major abdominal surgeries and it’s fentanyl sparing effect in a tertiary care hospital. Present study was Prospective Hospital‐based Interventional study, conducted in patients of age 18‐65 years, either gender, scheduled for elective major abdominal surgeries under general anesthesia. Patients were divided into 3 groups as Group C (placebo) Group PG 150 (Tab Pregabalin 150 mg) and Group PG 300 (Tab Pregabalin 300 mg) 1 hr before the surgery. In present study, difference in mean systolic blood pressure at post intubation (PI) post intubation (PI) 15/30/60 min, in PACU and average score was statistically significant. The difference in mean diastolic blood pressure at pre intubation, post intubation (PI) post intubation (PI) 15/30/60 min, in PACU and average score was statistically significant. The difference in mean diastolic blood pressure at post intubation (PI) 15/30/60 min, in PACU and average score was statistically significant. The difference of mean MRSS 1 hour before the operation, arrival in OT, in PACU at baseline 3‐6 hrs and 18‐24hrs was statistically significant. The difference of mean VAS SCORE in PACU at baseline 3‐6 hrs and 18‐24 hrs was statistically significant. Association of Intraop fentanyl top‐up, rescue Analgesia (paracetamol 1 gm IV) and rescue analgesia second analgesic statistically significant (p<0.0001) in group C as compared to group ‐PG 150 and group ‐PG 300. More intraoperative fentanyl, rescue analgesia (Paracetamol 1 gm) and second rescue analgesic was required in the control group compared to PG 150 and PG 300.

How to cite this article:

Sheikh Monazzam Hossain, Sritam Mohanty, Bani Parvati Magda Hembrom and Divya Chandra. Randomized Control Trial of Two Doses of Pregabalin as a Premedication for General Anaesthesia in Major Abdominal Surgeries and it’s Fentanyl Sparing Effect in a Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.2.141.147
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.2.141.147