Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Malaria is a major health problem in India leading to anemia, thrombocytopenia and leukopenia and also damages the kidneys and liver if left untreated. Evaluation of hematological parameters and biochemical correlation play an important role in malaria. The aims were to analyze the distribution of demographic data, clinical and pathological characteristics, hematological parameters and biochemical tests in malaria. From January to December 2022, a retrospective observational study using a cross‐sectional approach was conducted at Rama medical college and Research Centre. The study included 47 malaria cases and 47 healthy controls. The study examined symptoms and frequency of changes in hematological and biochemical parameters. Laboratory values were recorded and analyzed for associations. Data were evaluated using SPSS version 26 (trial version), compared the study groups with the control group using standard t‐tests to identify statistically significant differences. The Anova test was used to analyze biochemical tests. Findings with a p‐value below 0.05 were deemed to be of statistical significance. P. vivax was the most commonly observed species, at 43 (91%), while P. falciparum accounted for 4 (9%) of cases. Out of 47 cases, 31 were males., the majority of the cases belonged to people 13‐30 years of age. The most frequent hematological abnormalities were normochromic normocytic anemia and thrombocytopenia. The study shows significant mean values for hemoglobin (HB), hematocrit (HCT), red cell distribution width (RDW), total leukocyte count (TLC) and platelet count (PC), but not for mean cell volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. The correlation of hematological parameters with parasitemia grades was statistically insignificant. Hyperbilirubinemia was the most common. Blood urea was elevated in more cases than creatinine. Plasmodium vivax was the most common malaria species in our region, predominantly affecting males of young to middle age. Early diagnosis and management could be facilitated by monitoring HB, HCT, RDW, TLC and platelet values. Kidney and liver function assessments could prevent organ damage.
How to cite this article:
Manoj Sahani and Neelam Anuragi. Evaluation of Hematological Parameters with Biochemical Correlation in Malaria a Cross‐Sectional Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.450.455
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.450.455