Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
In the last few decades, with advanced modern technology and discoveries in pharmacology, the human life span has increased. However, sedentary lifestyles and easy access to calorie‐dense food have resulted in the growth of obesity and a significant rise in non‐communicable diseases, resulting in increased morbidities. Though genetic predisposition remains an important contributing factor, epigenetic modifications and environmental factors may play an essential role in the development of obesity in early life, including intrauterine and post‐natal stages. Understanding the interaction between these factors is necessary as these are modifiable and can be the target of therapeutic and pharmacological interventions, thus offering hope to combat obesity effectively. While genetic studies identify obesity‐linked genes, epigenetic research explores the factors related to lifestyle and environment and how they can alter gene expressions and are passed on to future generations. This article discusses the interplay of these variables in the dysregulation of energy metabolism and the role of current and future therapeutic strategies to intervene in obesity at an early stage.
How to cite this article:
Anamika Chakraborty Samant, Ajoy Tewari and Hemali Jha. Unraveling Childhood Obesity: An Overview on the Interplay of Genetics, Epigenetics and Environmental Factors.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.436.444
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.436.444