Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Prognostic Value of Atherogenic Index of Plasma, Cardiac Risk Ratio and hs‐CRP in Cardiovascular Risk Assessment among Diabetic Nephropathy Patients
Himani M. Jheetay, Alankrata Jain, Rajendra Ramachandra Mane and Sanket Jheetay
Page: 424-429 | Received 29 Aug 2024, Published online: 01 Oct 2024
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Abstract
Diabetic Nephropathy (DN) is a significant microvascular complication of type 2 diabetes mellitus (T2DM) that increases cardiovascular morbidity and mortality. The Atherogenic Index of Plasma (AIP), Cardiac Risk Ratio (CRR) and high‐sensitivity C‐reactive protein (hs‐CRP) are potential markers for assessing cardiovascular risk in DN patients. This study aimed to investigate the prognostic value of these markers in predicting cardiovascular risk in DN patients. To evaluate the relationship between lipid profile markers (AIP, CRR) and inflammatory marker (hs‐CRP) in predicting cardiovascular risk in DN patients and to compare these markers between DN patients and healthy controls. This cross‐sectional observational study was conducted at a tertiary care hospital over one year. A total of 70 DN patients and 70 age‐and sex‐matched healthy controls were included. Lipid profiles, hs‐CRP levels, CRR and AIP were measured in all participants. The relationships between these markers and cardiovascular risk were analysed using appropriate statistical tests. DN patients had significantly higher total cholesterol, triglycerides and hs‐CRP levels, along with lower HDL levels compared to healthy controls. AIP and CRR were also significantly elevated in DN patients. Patients with macroalbuminuria had significantly higher hs‐CRP, CRR and AIP compared to those with microalbuminuria, indicating greater cardiovascular risk. A majority of DN patients with high LDL levels also had hs‐CRP levels above 3 mg/L, compounding cardiovascular risk. Elevated AIP, CRR and hs‐CRP are strongly associated with increased cardiovascular risk in DN patients, particularly those with macroalbuminuria. These markers provide a more comprehensive assessment of cardiovascular risk than traditional lipid measures alone, underscoring the importance of combining lipid and inflammatory markers in evaluating and managing cardiovascular risk in DN patients.
How to cite this article:
Himani M. Jheetay, Alankrata Jain, Rajendra Ramachandra Mane and Sanket Jheetay. Prognostic Value of Atherogenic Index of Plasma, Cardiac Risk Ratio and hs‐CRP in Cardiovascular Risk Assessment among Diabetic Nephropathy Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.424.429
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.424.429