Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Neonatal seizures are a significant neurological concern that often indicate an underlying disorder. Prompt identification and treatment of biochemical abnormalities contributing to seizures are crucial to reducing morbidity and long‐term neurological impairment. The study aimed to identify common metabolic disturbances that could guide timely and targeted interventions. This hospital based cross sectional observational study was conducted in a neonatal intensive care unit (NICU) over a period of 12 months. Neonates who presented with clinically diagnosed or electrographically confirmed seizures were included in the study. Detailed clinical histories were recorded. Biochemical investigations, including serum electrolytes, blood glucose, calcium, magnesium and arterial blood gas (ABG) analyses, were performed to identify metabolic causes. The data were analyzed to determine the frequency of abnormalities and their correlation with neonatal seizures. Out of 76 neonates, 82% exhibited at least one biochemical abnormality. hypoglycemia was the most common finding (34.2%), followed by Hypocalcemia (25%) and Hyponatremia and hypernatremia were observed in 11.8% and 9.2% of cases, respectively. Metabolic acidosis was detected in 18% of neonates. Early‐onset seizures (<72 hours) were more frequently associated with hypoglycemia and hypocalcemia. Biochemical abnormalities are prevalent in neonates with seizures, with hypocalcemia and hypoglycemia being the most common. Routine biochemical screening in neonatal seizures can facilitate prompt treatment and improve neurological outcomes.
How to cite this article:
Kyasa Srinivas and Sai Brigisha Kyasa. A Study to Assess Biochemical Abnormalities in Neonatal Seizures.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.347.351
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.347.351