Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Dengue fever continues to be a significant public health problem in India. It is a common viral disease, especially in tropical regions. The incidence increases immediately after the monsoon period, coinciding with mosquito breeding in stagnant water. The disease has a varied clinical presentation characterized by sudden onset fever lasting 3‐5 days, intense headache, myalgia, retro‐orbital pain, anorexia, gastrointestinal disturbances and rash. Complete Blood Count (CBC) values typically show thrombocytopenia as the predominant finding. Most thrombocytopenic patients also exhibit leucopenia with lymphocytosis, which affects the disease prognosis in the initial days of NS1 antigen‐positive Dengue fever patients. To evaluate hematological parameters in NS1 antigen positive patients with clinical manifestations of dengue fever at a tertiary care hospital. This study was conducted at the Mediciti Institute Of Medical Sciences in Ghanpur, Telangana state, from January 2023 to March 2024. A total of 250 patients were admitted with fever during this period, with 100 cases testing positive for the NS1 Antigen. The majority of dengue infection cases were observed in the 18‐30 years age group (56%). Thrombocytopenia was present in 84% of patients, while 38% exhibited leucopenia and 16% had hematocrit values exceeding 45%. Platelet parameters among those with thrombocytopenia indicated elevated mean platelet volume (MPV) and platelet distribution width (PDW). In our study, we observed that as thrombocytopenia worsens in dengue infection, there is a concurrent increase in mean platelet volume (MPV) and platelet distribution width (PDW). A decrease in plateletcrit (PCT) also signifies the severity of the infection. Although we did not evaluate immature platelet fraction (IPF) levels, assessing these could potentially assist clinicians in refining treatment strategies. Further daily evaluations and larger studies are necessary to validate these findings.
How to cite this article:
Sama Snehaja Reddy, Sabbineni Ramya, Kalyani Vemavarapu and Bijjam Rajashekar Reddy. A Study of Hematological Profile in NS1 Antigen Positive Dengue Fever Patients at Tertiary Care Center.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.315.320
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.315.320