Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Respiratory infections are a leading cause of morbidity and mortality globally, with severity ranging from mild to life‐threatening conditions. Biomarkers such as Platelet Count, Neutrophil‐to‐Lymphocyte Ratio (NLR) and Serum IL‐6 levels have been investigated for their potential to assess the severity of these infections. This study aims to evaluate the relationship between these biomarkers and the severity of respiratory infections. A prospective observational study was conducted at the Department of Respiratory Medicine, Mamata Academy of Medical Sciences, Hyderabad, involving 150 patients with respiratory infections. Demographic and clinical data were collected, including biomarker levels measured upon admission: Platelet Count using an automated hematology analyzer, NLR derived from the complete blood count and Serum IL‐6 levels measured via ELISA. Statistical analyses included ANOVA, correlation and regression analyses to explore relationships between biomarkers and severity levels. The study found that mean Platelet Count decreased, NLR and Serum IL‐6 levels were elevated in severe cases, reflecting heightened systemic inflammation. Correlation analysis revealed a strong positive relationship between Platelet Count and NLR while correlations between Platelet Count and Serum IL‐6 and NLR and Serum IL‐6 were weak and not statistically significant. Regression analysis identified NLR as a significant predictor of IL‐6 levels, highlighting its role in severe inflammation, whereas Platelet Count did not significantly predict IL‐6 levels. This study found that NLR and Serum IL‐6 are valuable biomarkers for assessing the severity of respiratory infections, with NLR showing a significant association with IL‐6 levels, indicating systemic inflammation. Platelet Count did not consistently correlate with severity, highlighting the need for a multi‐marker approach. Integrating NLR and IL‐6 into clinical assessments could improve patient stratification and management of respiratory infections.
How to cite this article:
R. Prathyusha Yalamachi and Devi Samuel Priyaranjan. Role of Platelet Count, Lymphocyte Ratio and Serum il‐6 in Assessing Severity of Respiratory Infections: An Institutional Study.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.240.245
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.240.245