Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Psoriasis is a chronic, disfiguring, proliferative and inflammatory ailment of skin characterized by keratinocyte hyper‐proliferation, abnormal keratinocyte differentiation and immune‐cell infiltration into the epidermis and dermis. The ailment is extremely inconstant in duration and spell of flares. Vitamin D is a fat soluble steroid hormone. 25‐hyroxy vitamin D is the most stable form with a half‐life of 2‐3 weeks, hence reliable medical indicator of vitamin D status. Vitamin D has pleotropic functions. Various studies have reported the involvement of vitamin D in the pathogenesis of different skin diseases, including Psoriasis. Lesions begin as erythematous papules that gradually enlarge into rich red (also referred to as salmon pink) plaques. The shape of plaque and the amount of scaling are variable, but most lesions are covered by silvery white scaling. This case‐control study included Ninety outpatients. Fifty‐five patients with psoriasis were selected consecutively from the dermatology outpatient department. Thirty‐five age‐ and sex‐matched control subjects were selected among healthy volunteers who were the attendants of patients other than psoriasis. The diagnosis of plaque psoriasis was made clinically. Inclusion criteria for patients were age between 18 to 65 years, not treated with oral and topical steroids, immunosuppressant and vitamin D supplements, not undergoing current phototherapy and absence of chronic inflammatory diseases like systemic lupus erythematosus, multiple sclerosis, inflammatory disease and malignancy. For control subjects, all inclusion criteria were the same as for cases except for the absence of psoriasis. The mean ages of the both groups were 42.2±5.4 and 40.7±3.6 years respectively and their difference in means was not statistically significant (P>0.05). The two groups were therefore comparable. The mean BMI of both groups were 23.1±2.9 and 23.5±2.8 respectively. The difference between the means was also not statistically significant. (P>0.05). A statically significant difference (P<0.05) was observed when the mean vitamin‐D level of the cases (17.8±8.8) and controls (20.9±12.4) were compared. Eighty one percent of the cases and 71.4% of the control subjects had vitamin‐D deficiency. Six percentages (2 cases) of psoriasis cases had sufficient level of serum vitamin D, whereas the majority 81.8% (45 cases) had deficient vitamin‐D levels. About 14.5% (8 cases) had insufficient vitamin‐D values. Mild, moderate and severe PASI groups had the following mean serum vitamin D levels, 31.2±7.1, 20.5±7.2 and 12.3±3.9 respectively and a statistically significant difference was observed between them (P<0.001). The study found a signi cant relationship between vitamin D and psoriasis.
How to cite this article:
Nina Nimma, Chetana Panabaka and Farah Naaz Hashmi. Assessment of Vitamin D level in Patients With Psoriasis and it’s Correlation With Disease Severity.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.1.296.300
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.1.296.300