Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
In the present study, 50 patients of melasma attending outpatient department (OPD) of Dermatology Venereology and Leprology. Patients were diagnosed clinically and by wood's lamp and hand lens examination, and were randomly divided into two treatment groups, group‐A: Patients on Glycolic acid and group‐B: Patients on Salicylic acid. Majority of the patients 24 patients (48%) were in the age group of 40‐50 years, with female predominance 42 patients (84%), with F: M ratio 4:1.In the present study, the duration of disease was found to be 1‐2 years in 26 patients (52%). The average duration of disease was 2.78 years. Cosmetic use was seen as an exacerbating factor in 8 patients (16%).In the present study, centrofacial type was seen in 47 patients (94%), followed by malar type in 2 patients (4%) and mandibular type in only 1 patient (2%). In the present study, epidermal type was seen in 31 patients (62%) followed by mixed type in 17 patients (34%) and dermal type in only 2 patients (4%).The mean modified MASI scores in Glycolic acid were 6.10 (Day 1), 5.72 (2 weeks), 5.29 (4 weeks), 4.86 (6 weeks), 4.42 (8 weeks), 4.03 (16 weeks).The percentage change of the final score from that of baseline (Day1) of Glycolic acid was 33.89%.The mean modified MASI scores in Salicylic acid were 6.70 (Day 1), 6.34 (2 weeks), 5.84 (4 weeks), 5.42 (6 weeks), 5.07 (8 weeks), 4.84 (16 weeks).The percentage change of the final score from that of baseline (Day 1) of Salicylic acid was 27.72%. After completion of 16 weeks, the response in each group was graded. Glycolic acid showed very good response in 2 patients (8%), good response in 4 patients (16%), moderate response in 10 patients (40%), mild response in 8 patients (32%).Salicylic acid showed good response in 2 patients (8%), moderate response in 9 patients (36%), mild response in 12 patients (48%). No patient showed very good response. Over all very good response seen in 2 patients (4%), good response in 6 patients (12%), moderate response in 19 patients (38%), mild response in 20 patients (40%). In the present study, 3 patients discontinued 1 patient from the Glycolic acid group., she was a student not getting regular leaves. 2 patients were housewives having unrealistic expectations. The adverse effects during treatment were burning, erythema and post‐ inflammatory hyper pigmentation, which were tolerable. So the chemical peels (Glycolic acid and Salicylic acid) can be safely used in the treatment of melasma with minimal side effects.
How to cite this article:
B. Sudha Madhuri, Ravipati Haritha and Vasepalli Ramachandra Reddy. A Comparative Analysis of 20% Salicylic Acid Peel and 35% Glycolic Acid in Melasma.
DOI: https://doi.org/10.36478/10.36478/makrjms.2022.4.120.124
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2022.4.120.124