Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Stroke is one of the important causes for long term disability and second leading cause of death worldwide. Two thirds of stroke deaths worldwide occur in developing countries. Incidence and prevalence of stroke has been steadily increasing in India. Incidence rate of stroke is approaching western figures of 145/100000 population. Increasing interest has been focused on the role of hyperglycaemia in the evolution of acute ischaemic stroke (AIS). Hyperglycaemia arises in 30‐40% of patients with acute ischaemic stroke, most of these individuals do not have history of diabetes mellitus. The study subjects consisted of 100 consecutive patients who presented to the Hospital with Acute ischaemic stroke within 24 hrs of symptom onset and had capillary blood glucose (CBG) measured on presentation. Hyperglycemia was defined as CBG >140 mg/dl. Patients with hyperglycemia were then stratified into those with stress hyperglycaemia, newly detected diabetes mellitus and with pre‐existing diabetes mellitus (DM) for the purpose of analysis. Outcome of stroke in terms of functional impairment and 90 day mortality were studied. Patients with hyperglycaemia exhibited significantly greater functional impairment (P<0.0001) than those with normoglycemia. Outcome was poor in patients with hyperglycaemia. Stroke severity (P<0.001) and functional impairment (P<0.0001) were both significantly worse in patients with hyperglycaemia and no prior history of DM, when compared to patients with hyperglycaemia and previously diagnosed DM. Hyperglycaemia at stroke onset is associated with higher risk of poor outcome independent of the other variables. Patients with hyperglycemia at stroke onset, without prior history of DM have particularly poor prognosis, than that of patients with known diabetes.
How to cite this article:
Seethepalli Venkata Ramana and James Milton Aifred. Analysis of Glycaemic Levels as an Independent Predictor of Outcome in Acute Ischaemic Stroke.
DOI: https://doi.org/10.36478/10.36478/makrjms.2016.6.730.734
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2016.6.730.734