Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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To Compare 10mcg of Dexmedetomidine and 30mcg of Clonidine as an Adjuvant to 15mg of Intrathecal Isobaric Ropivacaine 0.75% for Elective Lower Abdominal and Lowerlimb Surgeries
B.J. Kavitha Kumari and Raja Damarla
Page: 206-213 | Received 12 Sep 2013, Published online: 31 Oct 2013
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Abstract
The present study was undertaken to compare the efficacy and the safety of dexmedetomidine and clonidine as an intrathecal adjuvant to isobaric 0.75% ropivacaine. 100 Patients involved in this study were randomly divided into two groups, Group C and Group D of 50 patients each. Group C received intrathecal 0.75% isobaric Ropivacaine 15mg (2 mL)+30mcg Clonidine in 0.5 mL normal saline (Total 2.5 mL). Group D received intrathecal 0.75% isobaric Ropivacaine 15mg (2mL)+10mcg Dexmedetomidine in 0.5 mL normal saline (Total 2.5mL). The mean time taken from the onset of sensory blockade to regression to T12 level was longer in Group D (199.7±34.067 minutes) as compared to Group C (151.7±22.533 minutes). This difference was statistically significant. (p value=0.001). The trend of increase in VAS score was earlier in Group C as compared to Group D, which was statistically significant between 90 to 210 minutes post operatively (p value<0.05). The mean time to first post operative analgesic requirement was longer in Group D as compared to Group C. In Group C, the mean time taken was 267.6±32.736 minutes, whereas in Group D it was 356.9±58.43 minutes. This result was statistically significant (p value<0.001). The mean time taken to achieve complete motor blockade in Group C was 12.66±1.520 minutes whereas in Group D it was 11.14±1.807 minutes. On comparing the groups this difference was statistically significant. The trend in return of Modified Bromage Score to 0 was earlier in Group C as compared to Group D which was statistically significant between the two groups at 0 min, 30 mins, 60 mins, 90 mins and 120 minutes post operatively.(p value<0.05).The mean time to full motor recovery was longer in Group D as compared to Group C. In Group C the mean time taken was 197.5±25.659 minutes, whereas in Group D it was 290.9±50.21 minutes. This result was statistically significant (p value<0.001). There was a statistically significant fall in systolic and diastolic blood pressure within Groups C and D from 5 minutes to 180 minutes. However, on comparing the two groups, this fall in blood pressure was not statistically significant.(P>0.05). On comparing the side effects, there was no statistically significant difference between Group C and Group D in the incidence of nausea, vomiting, hypotension, or bradycardia (p>0.05).
How to cite this article:
B.J. Kavitha Kumari and Raja Damarla. To Compare 10mcg of Dexmedetomidine and 30mcg of Clonidine as an Adjuvant to 15mg of Intrathecal Isobaric Ropivacaine 0.75% for Elective Lower Abdominal and Lowerlimb Surgeries.
DOI: https://doi.org/10.36478/10.36478/makrjms.2013.206.213
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2013.206.213